SGC 707

Catalog # Availability Size / Price Qty
5367/50
5367/10

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SGC 707 | Protein Arginine Methyltransferase Inhibitors
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Description: Potent and selective allosteric inhibitor of PRMT3

Chemical Name: 1-(Isoquinolin-6-yl)-3-[2-oxo-2-(pyrrolidin-1-yl)ethyl] urea

Purity: ≥98%

Product Details
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Biological Activity

SGC 707 is a potent allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) (IC50 = 31 nM). Inhibits PRMT3-mediated methyltransferase activity in vitro. Displays >100-fold selectivity against 31 other methyltransferases and 250 other non-epigenetic targets. Decreases H4R3me2a levels in HEK293 cells in vitro.

Negative control also available.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of SGC 707 is reviewed on the chemical probes website.

Technical Data

M.Wt:
298.34
Formula:
C16H18N4O2
Solubility:
Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC 707 probe summary on the SGC website.
Other Product-Specific Information:

Product Datasheets

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