Chemical Name: N-[5-[[3-Cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl]amino]-2-methylphenyl]propanamide
Biological ActivitySGC CK2-1 is a potent inhibitor of casein kinase 2 (CK2) with activity at both the CK2A2 and CK2A1 isoforms (IC50 values are 2.3-16 nM and 4.2-36 nM respectively). SGC CK-1 also inhibits DYRK2 (IC50 = 440 nM).
External Portal InformationChemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of SGC CK2-1 is reviewed on the chemical probes website.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Citation for SGC CK2-1
The citations listed below are publications that use Tocris products. Selected citations for SGC CK2-1 include:
1 Citation: Showing 1 - 1
Phosphorylation of FAM134C by CK2 controls starvation-induced ER-phagy.
Authors: Carmine Et al.
Sci Adv 2022;8:eabo1215
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