Chemical Name: 6-[[6-(1-Methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]quinoline
Biological ActivityPotent and selective c-MET kinase inhibitor (IC50 = 4nM). Exhibits minimal inhibition against a panel of 213 other protein kinases (at 1 μM). Suppresses growth of tumor xenografts derived from human glioblastoma, lung and gastric cancer cells.
External Portal InformationChemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of SGX 523 is reviewed on the chemical probes website.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo.
Buchanan et al.
Citations for SGX 523
The citations listed below are publications that use Tocris products. Selected citations for SGX 523 include:
2 Citations: Showing 1 - 2
Matrix stiffness modulates infection of endothelial cells by Listeria monocytogenes via expression of cell surface vimentin.
Authors: Bastounis Et al.
Mol Biol Cell 2018;29:1571
Adhesion to the host cell surface is sufficient to mediate Listeria monocytogenes entry into epithelial cells.
Authors: Ortega Et al.
Mol Biol Cell 2017;28:2945
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