Potent and selective c-MET kinase inhibitor (IC50
= 4nM). Exhibits minimal inhibition against a panel of 213 other protein kinases (at 1 μ
M). Suppresses growth of tumor xenografts derived from human glioblastoma, lung and gastric cancer cells.
Soluble to 20 mM in DMSO
Store at +4°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo.
Buchanan et al.