SHIN 1

Tocris Bioscience | Catalog # 6998

Potent SHMT inhibitor
Tocris Bioscience

Key Product Details

Description

Potent SHMT inhibitor
View all Other Transferase Inhibitors »

Product Description

SHIN 1 is a potent serine hydroxymethyltransferase (SHMT) inhibitor (IC50 values are 5 and 13 nM at SHMT1 and SHMT2, respectively). Inhibits growth of HCT-116 cells in vitro (IC50 = 870 nM). Unstable in liver microsome assays.

Licensing Information

Sold under license from Princeton University.

Product Specifications for SHIN 1

Molecular Weight

400.48

Formula

C24H24N4O2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

6-Amino-1,4-dihydro-4-[5-(hydroxymethyl)[1,1'-biphenyl]-3-yl]-3-methyl-4-(1-methylethyl)pyrano[2,3-c]pyrazole-5-carbonitrile

CAS Number

2146095-85-2

PubChem ID

134335083

InChI Key

VVVOFJZXKJKHTD-UHFFFAOYSA-N

SMILES

CC(C1(C2=CC(C3=CC=CC=C3)=CC(CO)=C2)C4=C(OC(N)=C1C#N)NN=C4C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.02 50

Preparing Stock Solutions for SHIN 1

The following data is based on the product molecular weight 400.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.99 mL 24.97 mL 49.94 mL
2.5 mM 1.00 mL 4.99 mL 9.99 mL
5 mM 0.50 mL 2.50 mL 4.99 mL
25 mM 0.10 mL 0.50 mL 1.00 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

Product Documents for SHIN 1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SHIN 1

For research use only

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