Home / Voltage-gated Potassium Channel Blockers / ShK-Dap22

ShK-Dap22

Catalog #: 3220 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3220/100U
ShK-Dap22
1 Image
Description: Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro

Purity: ≥95%

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Biological Activity

ShK-Dap22 is an extremely potent KV1.3 channel blocker (Kd = 23 pM for mKV1.3 currents). Selective for KV1.3 over other mammalian potassium channels (IC50 values are 23, 1800, 10500, 37000 and 39000 pM for mKV1.3, mKV1.1, hKV1.6, mKV1.4 and rKV1.2 respectively, and >100000 pM for hKV1.5, mKV1.7, hKV3.1, rKV3.4 and hKCa4). Suppresses T cell activation in vitro (IC50 < 500 pM).

Technical Data

M.Wt:
4012.7
Formula:
C166H268N54O48S7
Sequence:
RSCIDTIPKSRCTAFQCKHSMXYRLSFCRKTCGTC

(Modifications: Disulfide bridges: 3-35, 12-28, 17-32, X= Dap)

Solubility:
Soluble to 1 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
220384-25-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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