Catalog Number: 3220
Biological Activity
Extremely potent KV1.3 channel blocker (Kd = 23 pM for mKV1.3 currents). Selective for KV1.3 over other mammalian potassium channels (IC50 values are 23, 1800, 10500, 37000 and 39000 pM for mKV1.3, mKV1.1, hKV1.6, mKV1.4 and rKV1.2 respectively, and >100000 pM for hKV1.5, mKV1.7, hKV3.1, rKV3.4 and hKCa4). Suppresses T cell activation in vitro (IC50 < 500 pM).
Technical Data
  • M.Wt:
    4012.7
  • Formula:
    C166H268N54O48S7
  • Sequence:
    RSCIDTIPKSRCTAFQCKHSMXYRLSFCRKTCGTC

    (Modifications: Disulfide bridges: 3-35,12-28,17-32), X= Dap)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
    220384-25-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. ShK-Dap22, a potent KV1.3-specific immunosuppresive polypeptide.
    Kalman et al.
    J.Biol.Chem., 1998;273:32697
  2. Hypoxia modulates early events in T cell receptor-mediated activation in human T lymphocytes via KV1.3 channels.
    Robbins et al.
    J.Physiol., 2005;564:131

Have you used ShK-Dap22?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 

Feedback

Customer Information