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ShK-Dap22

3220 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3220/100U
Cat.No. 3220 - ShK-Dap22 | Arg-Ser-Cys-Ile-Asp-Thr-Ile-Pro-Lys-Ser-Arg-Cys-Thr-Ala-Phe-Gln-Cys-Lys-His-Ser-Met-Dap-Tyr-Arg-Leu-Ser-Phe-Cys-Arg-Lys-Thr-Cys-Gly-Thr-Cys | CAS No. 220384-25-8
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Description: Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro
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Biological Activity

Extremely potent KV1.3 channel blocker (Kd = 23 pM for mKV1.3 currents). Selective for KV1.3 over other mammalian potassium channels (IC50 values are 23, 1800, 10500, 37000 and 39000 pM for mKV1.3, mKV1.1, hKV1.6, mKV1.4 and rKV1.2 respectively, and >100000 pM for hKV1.5, mKV1.7, hKV3.1, rKV3.4 and hKCa4). Suppresses T cell activation in vitro (IC50 < 500 pM).

Technical Data

M.Wt:
4012.7
Formula:
C166H268N54O48S7
Sequence:
RSCIDTIPKSRCTAFQCKHSMXYRLSFCRKTCGTC

(Modifications: Disulfide bridges: 3-35,12-28,17-32), X= Dap)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Store at -20°C
CAS No:
220384-25-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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