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ShK-Dap22

   
Product Datasheet
Catalog Number:3220
Chemical Name:
Product Details
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Biological Activity
Extremely potent KV1.3 channel blocker (Kd = 23 pM for mKV1.3 currents). Selective for KV1.3 over other mammalian potassium channels (IC50 values are 23, 1800, 10500, 37000 and 39000 pM for mKV1.3, mKV1.1, hKV1.6, mKV1.4 and rKV1.2 respectively, and >100000 pM for hKV1.5, mKV1.7, hKV3.1, rKV3.4 and hKCa4). Suppresses T cell activation in vitro (IC50 < 500 pM).
Technical Data
  • M.Wt:
    4012.7
  • Formula:
    C166H268N54O48S7
  • Sequence:
    RSCIDTIPKSRCTAFQCKHSMXYRLSFCRKTCGTC

    (Modifications: Disulfide bridges: 3-35,12-28,17-32), X= Dap)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
    220384-25-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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