Extremely potent KV
1.3 channel blocker (Kd
= 23 pM for mKV
1.3 currents). Selective for KV
1.3 over other mammalian potassium channels (IC50
values are 23, 1800, 10500, 37000 and 39000 pM for mKV
1.4 and rKV
1.2 respectively, and >100000 pM for hKV
3.4 and hKCa
4). Suppresses T cell activation in vitro
< 500 pM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
ShK-Dap22, a potent KV1.3-specific immunosuppresive polypeptide.
Kalman et al.
Hypoxia modulates early events in T cell receptor-mediated activation in human T lymphocytes via KV1.3 channels.
Robbins et al.