Catalog Number: 5964
Chemical Name: 1-(2-Pyridinyl)ethanone 2-(1-methyl-1H-benzimidazol-2-yl)hydrazone hydrochloride
Biological Activity
Potent steroid receptor coactivator 3 (SRC-3) inhibitor. Reduces SRC1, SRC2 and SRC3 levels in breast cancer cell lines. Inhibits cell growth (IC50 = 3.4 nM), induces apoptosis and attenuates migration of MDA-MB48 breast cancer cells in vitro. Inhibits tumor growth in a MDA-MB48 cell breast cancer mouse model. Orally available.
Technical Data
  • M.Wt:
    301.78
  • Formula:
    C15H15N5.HCl
  • Solubility:
    Soluble to 50 mM in water and to 20 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3.
    Song et al.
    Proc.Natl.Acad.Sci.U.S.A., 2016;113:4970
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