Chemical Name: 1-(2-Pyridinyl)ethanone 2-(1-methyl-1H-benzimidazol-2-yl)hydrazone hydrochloride
Biological ActivitySI-2 hydrochloride is a potent steroid receptor coactivator 3 (SRC-3) inhibitor. Reduces SRC1, SRC2 and SRC3 levels in breast cancer cell lines. Inhibits cell growth (IC50 = 3.4 nM), induces apoptosis and attenuates migration of MDA-MB48 breast cancer cells in vitro. Inhibits tumor growth in a MDA-MB48 cell breast cancer mouse model. Orally available.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3.
Song et al.
Citation for SI-2 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for SI-2 hydrochloride include:
1 Citation: Showing 1 - 1
SRC3 acetylates calmodulin in the mouse brain to regulate synaptic plasticity and fear learning.
Authors: Wei Et al.
J Biol Chem 2021;297:101044
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