Potent steroid receptor coactivator 3 (SRC-3) inhibitor. Reduces SRC1, SRC2 and SRC3 levels in breast cancer cell lines. Inhibits cell growth (IC50
= 3.4 nM), induces apoptosis and attenuates migration of MDA-MB48 breast cancer cells in vitro
. Inhibits tumor growth in a MDA-MB48 cell breast cancer mouse model. Orally available.
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Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3.
Song et al.