SI-2 hydrochloride

Key Product Details

Product Description

SI-2 hydrochloride is a potent steroid receptor coactivator 3 (SRC-3) inhibitor. Reduces SRC1, SRC2 and SRC3 levels in breast cancer cell lines. Inhibits cell growth (IC₅₀ = 3.4 nM), induces apoptosis and attenuates migration of MDA-MB48 breast cancer cells in vitro. Inhibits tumor growth in a MDA-MB48 cell breast cancer mouse model. Orally available.

Product Specifications for SI-2 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SI-2 hydrochloride

The following data is based on the product molecular weight 301.78.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.63 mL	33.14 mL	66.27 mL
2.5 mM	1.33 mL	6.63 mL	13.25 mL
5 mM	0.66 mL	3.31 mL	6.63 mL
25 mM	0.13 mL	0.66 mL	1.33 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Song Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3. Proc.Natl.Acad.Sci.U.S.A. 2016 PMID: 27084884

Product Documents for SI-2 hydrochloride