Chemical Name: 1-(4-Chlorophenyl)-N,N-dimethyl-α-(2-methylpropyl)cyclobutanemethanamine hydrochloride
Biological ActivitySibutramine hydrochloride is a 5-HT and noradrenalin re-uptake inhibitor (SNRI). Produces weight loss in rats via inhibition of food intake and increased energy expenditure. Antidepressant.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
In vivo criteria to differentiate monoamine reuptake inhibitors from releasing agents: sibutr. is a reuptake inhibitor.
Gundlah et al.
Comparison of the effects of sibutr. and other monoamine reuptake inhibitors on food intake in the rat.
Jackson et al.
The pharmacology of sibutr. hydrochloride (BTS 54524), a new antidepressant which induces rapid noradrenergic down-regulation.
Buckett et al.
Citation for Sibutramine hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Sibutramine hydrochloride include:
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