Sibutramine hydrochloride

Key Product Details

Product Description

Sibutramine hydrochloride is a 5-HT and noradrenalin re-uptake inhibitor (SNRI). Produces weight loss in rats via inhibition of food intake and increased energy expenditure. Antidepressant.

Product Specifications for Sibutramine hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Sibutramine hydrochloride

The following data is based on the product molecular weight 316.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

5 4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.16 mL	15.81 mL	31.61 mL
5 mM	0.63 mL	3.16 mL	6.32 mL
10 mM	0.32 mL	1.58 mL	3.16 mL
50 mM	0.06 mL	0.32 mL	0.63 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

• Gundlah In vivo criteria to differentiate monoamine reuptake inhibitors from releasing agents: sibutr. is a reuptake inhibitor. J.Pharmacol.Exp.Ther. 1997 PMID: 9353373
• Buckett The pharmacology of sibutr. hydrochloride (BTS 54524), a new antidepressant which induces rapid noradrenergic down-regulation. Prog.Neuro-Psychopharm.Biol.Psychiat.
• Jackson Comparison of the effects of sibutr. and other monoamine reuptake inhibitors on food intake in the rat. Br.J.Pharmacol. 1997 PMID: 9283714

Product Documents for Sibutramine hydrochloride