Catalog Number: 2290
Alternate Names: BTS 54-524
Chemical Name: 1-(4-Chlorophenyl)-N,N-dimethyl-α-(2-methylpropyl)cyclobutanemethanamine hydrochloride
Biological Activity
5-HT and noradrenalin re-uptake inhibitor (SNRI). Produces weight loss in rats via inhibition of food intake and increased energy expenditure. Antidepressant.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 5 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Comparison of the effects of sibutramine and other monoamine reuptake inhibitors on food intake in the rat.
    Jackson et al.
    Br.J.Pharmacol., 1997;121:1758
  2. In vivo criteria to differentiate monoamine reuptake inhibitors from releasing agents: sibutramine is a reuptake inhibitor.
    Gundlah et al.
    J.Pharmacol.Exp.Ther., 1997;283:581
  3. The pharmacology of sibutramine hydrochloride (BTS 54524), a new antidepressant which induces rapid noradrenergic down-regulation.
    Buckett et al.
    Prog.Neuro-Psychopharm.Biol.Psychiat., 1988;12:575

The citations listed below are publications that use Tocris products. Selected citations for Sibutramine hydrochloride include:

Showing Results 1 - 1 of 1

  1. Study on health hazards through medicines purchased on the Internet: a cross-sectional investigation of the quality of anti-obesity medicines containing crude drugs as active ingredients.
    Authors: Yoshida Et al.
    PLoS One
Tocris Small Molecules
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BTS 54-505 hydrochloride

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