Sibutramine hydrochloride

Catalog # Availability Size / Price Qty
2290/10
2290/50
Cat.No. 2290 - Sibutramine hydrochloride | C17H26NCl.HCl | CAS No. 84485-00-7
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Description: 5-HT and noradrenalin re-uptake inhibitor (SNRI)
Alternative Names: BTS 54-524

Chemical Name: 1-(4-Chlorophenyl)-N,N-dimethyl-α-(2-methylpropyl)cyclobutanemethanamine hydrochloride

Purity: ≥99%

Product Details
Citations (1)
Reviews

Biological Activity

5-HT and noradrenalin re-uptake inhibitor (SNRI). Produces weight loss in rats via inhibition of food intake and increased energy expenditure. Antidepressant.

Technical Data

M.Wt:
316.31
Formula:
C17H26NCl.HCl
Solubility:
Soluble to 5 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
84485-00-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Comparison of the effects of sibutramine and other monoamine reuptake inhibitors on food intake in the rat.
    Jackson et al.
    Br.J.Pharmacol., 1997;121:1758
  2. In vivo criteria to differentiate monoamine reuptake inhibitors from releasing agents: sibutramine is a reuptake inhibitor.
    Gundlah et al.
    J.Pharmacol.Exp.Ther., 1997;283:581
  3. The pharmacology of sibutramine hydrochloride (BTS 54524), a new antidepressant which induces rapid noradrenergic down-regulation.
    Buckett et al.
    Prog.Neuro-Psychopharm.Biol.Psychiat., 1988;12:575

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Citation for Sibutramine hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Sibutramine hydrochloride include:

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