Chemical Name: Ethyl 2-[[2-[2-[(2,3-Dihydro-1,4-benzodioxin-6-yl)amino]-2-oxoethyl]-1,2-dihydro-1-oxo-5-isoquinolinyl]oxy]propanoate
Biological ActivitySelective steroidogenic factor-1 (SF-1, NR5A1) inhibitor (IC50 values are 0.76, >33 and >33 μM at SF-1, RORα and VP16 respectively). Inhibits SF-1-dependent luciferase expression in HEK 293T cells in vitro (IC50 = 30 nM).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffolds.
Roth et al.
Potent, selective and cell penetrant inhibitors of SF-1 by functional ultra-high-throughput screening.
Madoux et al.
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