Simple Plex Discovery Control for Human Pro-Collagen I a 1

R&D Systems | Catalog # 897973

Control for use with Human Pro-Collagen I a 1 Simple Plex Assay Cartridge Kit
R&D Systems

Key Product Details

Species

Human

Product Summary for Simple Plex Discovery Control for Human Pro-Collagen I a 1

INTENDED USE AND DESCRIPTION: For use a quantitative control for the determination of human Pro-Collagen I α 1 concentrations in biological fluids. Controls are supplied lyophilized. Please refer to the lot specific certificate of analysis and Simple Plex Lyophilized Quality Control product insert for additional information.

Background: Pro-Collagen I alpha 1

Type I collagen is the most abundant structural protein of connective tissues such as skin, bone and tendon. It is synthesized as a procollagen molecule which is characterized by a 300 nm triple helical domain flanked by globular N- and C-terminal propeptides. The triple helical domain contains Gly-Xaa-Yaa triplets where Xaa and Yaa are frequently proline and hydroxyproline, respectively. The non-helical propeptides are removed by procollagen N- and C-proteinase activities so that the mature triple helices can self-assemble into collagen fibrils that provide tensile strength to tissues. Type I collagen is a heterotrimer that consists of two alpha 1(I) chains and one alpha 2(I) chain, although homotrimers consisting of three identical alpha 1(I) chains have also been described. This recombinant mini pro-alpha 1(I) collagen consists of a shortened alpha 1(I) chain with following domain structure from N- to C-terminus: N-propeptide, N-telopeptide, the 33 most N-terminal Gly-Xaa-Yaa repeats, the 33 most C-terminal Gly-Xaa-Yaa repeats, C-telopeptide and C-propeptide. The preparation contains a mixture of the full-length molecule, pN collagen I (alpha 1) and the C-terminal propeptide. This truncated pro-alpha 1(I) collagen is a substrate for procollagen N-proteinase and procollagen C-proteinase.

Long Name

Pro-Collagen I alpha 1

Additional Pro-Collagen I alpha 1 Products

Product Documents for Simple Plex Discovery Control for Human Pro-Collagen I a 1

Certificate of Analysis

To download a Certificate of Analysis, please enter your Simple Plex catalog number and lot number in the search boxes below.

Product Specific Notices for Simple Plex Discovery Control for Human Pro-Collagen I a 1

For research use only

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