Simple Plex Human CA125/MUC16 Cartridge
R&D Systems | Catalog # SPCKB-PS-000475
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Key Product Details
Assay Length
Sample Type & Volume Required Per Well*
Sensitivity
Assay Range
Simple Plex Human CA125/MUC16 Cartridge Summary
*The Sample Volume represented is based on the amount of sample incorporated into the reaction after taking into account the assay's minimum required dilution for a given matrix. Serial dilution may be necessary to achieve some of the final sample volumes represented.
Compatible Instruments
Ella Automated Immunoassay System
Product Specifications
Assay Type
Format
Species
Specificity
Cross-reactivity
Interference
Precision
Intra-Assay Precision (Precision within an assay) Each control was tested multiple times in one CA125 assay.
Inter-Assay Precision (Precision between assays) Replicates of each CA125 control were tested in multiple assays performed by at least three technicians using two lots of reagents for human CA125.
EDTA Plasma, Heparin Plasma, Serum
| Intra-Assay Precision | Inter-Assay Precision | |||
|---|---|---|---|---|
| Sample | 1 | 2 | 1 | 2 |
| n | 16 | 16 | 21 | 18 |
| Mean (mU/mL) | 2954 | 141,869 | 2885 | 130,993 |
| Standard Deviation | 55.9 | 3239 | 152 | 8524 |
| CV% | 1.9 | 2.3 | 5.3 | 6.5 |
Recovery for Simple Plex Human CA125/MUC16 Cartridge
Recovery for the human CA125 assays was evaluated at three different spiked concentrations of CA125 protein.
| Sample Type | Average % Recovery | Range % |
|---|---|---|
| EDTA Plasma (n=4) | 101 | 97-106 |
| Heparin Plasma (n=4) | 93 | 90-98 |
| Serum (n=4) | 95 | 88-99 |
Linearity
Samples containing and/or spiked with high concentrations of CA125 were serially diluted with Sample Diluent to produce samples within the dynamic range of the assay.
Scientific Data Images for Simple Plex Human CA125/MUC16 Cartridge
Simple Plex Human CA125 Assay Standard Curve
Data shown represents typical performance results for Lower Limit of Quantitation (LLOQ) and Upper Limit of Quantitation (ULOQ) for Simple Plex Human CA125 Assay. Assay range is 309-471,920 pg/mL.Preparation and Storage
Shipping
Stability & Storage
Background: CA125/MUC16
The CA125 antigen, also known as MUC16, is a mucin protein that may be found in type I transmembrane or secreted forms that are used monitor the progress of epithelial ovarian cancer therapy. Expression of isoforms, proteolytic cleavage, and heavy N- and O- linked glycosylation produce forms of human CA125 that can vary from 200-5000 kDa in size. It inhibits NK cell activity, which is thought to contribute to immune evasion in peritoneal cancer and pregnancy.
Long Name
Alternate Names
Entrez Gene IDs
Gene Symbol
Additional CA125/MUC16 Products
Product Documents for Simple Plex Human CA125/MUC16 Cartridge
Certificate of Analysis
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Product Specific Notices for Simple Plex Human CA125/MUC16 Cartridge
For research use only
Related Research Areas
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