Simple Plex Human Osteoprotegerin/OPG Cartridge
R&D Systems | Catalog # SPCKB-PS-000521
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Key Product Details
Assay Length
Sample Type & Volume Required Per Well*
Sensitivity
Assay Range
Simple Plex Human Osteoprotegerin/OPG Cartridge Summary
*The Sample Volume represented is based on the amount of sample incorporated into the reaction after taking into account the assay's minimum required dilution for a given matrix. Serial dilution may be necessary to achieve some of the final sample volumes represented.
Compatible Instruments
Ella Automated Immunoassay System
Product Specifications
Assay Type
Format
Species
Specificity
Cross-reactivity
Interference
Precision
Intra-Assay Precision (Precision within an assay) Each control was tested multiple times in one OPG assay.
Inter-Assay Precision (Precision between assays) Replicates of each OPG control were tested in multiple assays performed by at least three technicians using two lots of reagents for human OPG.
EDTA Plasma, Heparin Plasma, Serum
| Intra-Assay Precision | Inter-Assay Precision | |||
|---|---|---|---|---|
| Sample | 1 | 2 | 1 | 2 |
| n | 16 | 16 | 26 | 26 |
| Mean (pg/mL) | 231 | 12,102 | 242 | 11,197 |
| Standard Deviation | 16.3 | 976 | 23.5 | 1133 |
| CV% | 7.1 | 8.1 | 9.7 | 10.1 |
Recovery for Simple Plex Human Osteoprotegerin/OPG Cartridge
Recovery was not necessary as human OPG shows 5 points of natural linearity.
Linearity
Samples containing and/or spiked with high concentrations of human OPG were serially diluted with Sample Diluent to produce samples within the dynamic range of the assay
Scientific Data Images for Simple Plex Human Osteoprotegerin/OPG Cartridge
Simple Plex Human OPG Assay Standard Curve
Data shown represents typical performance results for Lower Limit of Quantitation (LLOQ) and Upper Limit of Quantitation (ULOQ) for Simple Plex Human OPG Assay. Assay range is 4.20-40,000 pg/mL.Preparation and Storage
Shipping
Stability & Storage
Background: Osteoprotegerin/TNFRSF11B
Osteoprotegerin (OPG), also known as OCIF and TNFRSF11B, is a secreted TNF superfamily receptor that regulates bone density. OPG is widely expressed and constitutively released as a homodimer by mesenchymal stem cells, fibroblasts, and endothelial cells. OPG functions as a decoy receptor for TRANCE/RANK L and TRAIL. OPG regulates the cell surface expression of TRANCE and its ability to stimulate osteoclastogenesis. Dysregulation of OPG/TRANCE interactions can lead to juvenile Paget’s disease, osteoporosis, bone loss, and vascular calcification.
Additional Osteoprotegerin/TNFRSF11B Products
Product Documents for Simple Plex Human Osteoprotegerin/OPG Cartridge
Certificate of Analysis
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Product Specific Notices for Simple Plex Human Osteoprotegerin/OPG Cartridge
For research use only
Related Research Areas
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Associated Pathways
