SIN-1 chloride

Tocris Bioscience | Catalog # 0756

Water-soluble NO donor
Tocris Bioscience

Key Product Details

Description

Water-soluble NO donor

Alternative Names

3-Morpholinylsydnoneimine chloride
View all Nitric Oxide Donor/Precursor Compounds »

Product Description

This compound (the active product of the prodrug SIN-10, molsidomine) acts as a vasodilator and inhibitor of platelet aggregation; longer acting than nitroprusside or nitroglycerin. Decreases myocardial necrosis and reperfusion-induced endothelial dysfunction in models of myocardial ischemia-reperfusion.

Product Specifications for SIN-1 chloride

Molecular Weight

206.63

Formula

C6H11ClN4O2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

Amino-3-morpholinyl-1,2,3-oxadiazolium chloride

CAS Number

16142-27-1

PubChem ID

197942

InChI Key

ZRFWHHCXSSACAW-UHFFFAOYSA-M

SMILES

NC1=C[N+](N2CCOCC2)=NO1.[Cl-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 20.66 100
DMSO 20.66 100

Preparing Stock Solutions for SIN-1 chloride

The following data is based on the product molecular weight 206.63.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.84 mL 24.20 mL 48.40 mL
5 mM 0.97 mL 4.84 mL 9.68 mL
10 mM 0.48 mL 2.42 mL 4.84 mL
50 mM 0.10 mL 0.48 mL 0.97 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 9 publications citing the usage of this product.

Product Documents for SIN-1 chloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SIN-1 chloride

For research use only

Customer Reviews for SIN-1 chloride (1)

5 out of 5
1 Customer Rating
5 Stars
100%
4 Stars
0%
3 Stars
0%
2 Stars
0%
1 Stars
0%

Have you used SIN-1 chloride?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card

Customer Images

Showing  1 - 1 of 1 review Showing All
Filter By:
Clear Filters X
  • SIN-1 inhibits the chlorinating activity of MPO
    Name: Christopher Trummer
    Species: Chemical
    Assay Type: In Vitro
    Verified Customer | Posted 10/15/2018
    Effects of SIN-1 (20 μM in pH 7.4, kept at 37 °C for 2 h) on the MPO (10 nM)-H2O2 (25 μM)-chloride system were analyzed by APF fluorescence measurements. Fluorescence intensities were measured every 30 s (up to 30 min) at 488/522 nm (excitation/emission wavelength) at 37 °C. SIN-1 inhibits the chlorinating capacity of MPO.
    SIN-1 chloride 0756

There are no reviews that match your criteria.

Showing  1 - 1 of 1 review Showing All