SIN-1 chloride

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SIN-1 chloride | CAS No. 16142-27-1 | Nitric Oxide Donor/Precursor Compounds
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Description: Water-soluble NO donor
Alternative Names: 3-Morpholinylsydnoneimine chloride

Chemical Name: Amino-3-morpholinyl-1,2,3-oxadiazolium chloride

Purity: ≥98%

Product Details
Citations (1)

Biological Activity

This compound (the active product of the prodrug SIN-10, molsidomine) acts as a vasodilator and inhibitor of platelet aggregation; longer acting than nitroprusside or nitroglycerin. Decreases myocardial necrosis and reperfusion-induced endothelial dysfunction in models of myocardial ischemia-reperfusion.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Inhibition of platelet aggregation and stimulation of guanylate cyclase by an anti-anginal agent molsidomine and its metabolite.
    Nishikawa et al.
    J.Pharmacol.Exp.Ther., 1982;220:183
  2. Molecular basis of the synergistic inhibition of platelet function by nitrovasodilators and activators of adenylate cyclase: inhibition of cyclic AMP breakdown by cyclic GMP.
    Maurice and Heslam
    Mol.Pharmacol., 1990;37:671
  3. Cardioprotection and attenuation of endothelial dysfunction by organic nitric oxide donors in myocardial ichemia-reperfusion.
    Siegfried et al.
    J.Pharmacol.Exp.Ther., 1992;260:668
  4. Biotransformation of molsidomine (SIN-10), a new anti-anginal agent in rats.
    Tanayama et al.
    Xenobiotica, 1974;4:175

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Citation for SIN-1 chloride

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