Chemical Name: Amino-3-morpholinyl-1,2,3-oxadiazolium chloride
Biological ActivityThis compound (the active product of the prodrug SIN-10, molsidomine) acts as a vasodilator and inhibitor of platelet aggregation; longer acting than nitroprusside or nitroglycerin. Decreases myocardial necrosis and reperfusion-induced endothelial dysfunction in models of myocardial ischemia-reperfusion.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Inhibition of platelet aggregation and stimulation of guanylate cyclase by an anti-anginal agent molsidomine and its metabolite.
Nishikawa et al.
Molecular basis of the synergistic inhibition of platelet function by nitrovasodilators and activators of adenylate cyclase: inhibition of cyclic AMP breakdown by cyclic GMP.
Maurice and Heslam
Cardioprotection and attenuation of endothelial dysfunction by organic nitric oxide donors in myocardial ichemia-reperfusion.
Siegfried et al.
Biotransformation of molsidomine (SIN-10), a new anti-anginal agent in rats.
Tanayama et al.
Citation for SIN-1 chloride
The citations listed below are publications that use Tocris products. Selected citations for SIN-1 chloride include:
1 Citation: Showing 1 - 1
Nitric oxide (NO)-induced activation of large conductance Ca2+-dependent K+ channels (BK(Ca)) in smooth muscle cells isolated from the rat mesenteric artery.
Authors: Mistry and Garland
Br J Pharmacol 1998;124:1131
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