Chemical Name: 1'-[4-[1-(4-Fluorophenyl)-1H-indol-3-yl]butyl]spiro[isobenzofuran-1(3H),4'-piperidine hydrochloride
Biological ActivitySiramesine hydrochloride is a high affinity σ receptor agonist (Ki values are 0.19 and 17 nM for σ2 and σ1 receptors, respectively). Displays anxiolytic and antidepressant effects in rodents. Also induces cell death in tumor cell lines.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Lu 28-179 labels a σ2-site in rat and human brain.
Søby et al.
The selective σ2-ligand Lu 28-179 has potent anxiolytic-like effects in rodents.
Sánchez et al.
Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes.
Česen et al.
Cell Death Des., 2013;4:e818
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