Home / General Sigma Receptor Ligands / Siramesine hydrochloride

Siramesine hydrochloride

Catalog #: 6740 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6740/5
6740/25
Siramesine hydrochloride | CAS No. 224177-60-0 | General Sigma Receptor Ligands
1 Image
Description: High affinity σ agonist (σ2 > σ1)

Chemical Name: 1'-[4-[1-(4-Fluorophenyl)-1H-indol-3-yl]butyl]spiro[isobenzofuran-1(3H),4'-piperidine hydrochloride

Purity: ≥98%

Product Details
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Siramesine hydrochloride is a high affinity σ receptor agonist (Ki values are 0.19 and 17 nM for σ2 and σ1 receptors, respectively). Displays anxiolytic and antidepressant effects in rodents. Also induces cell death in tumor cell lines.

Technical Data

M.Wt:
491.04
Formula:
C30H31FN2O.HCl
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
224177-60-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Lu 28-179 labels a σ2-site in rat and human brain.
    Søby et al.
    Neuropharmacology., 2002;43:95
  2. The selective σ2-ligand Lu 28-179 has potent anxiolytic-like effects in rodents.
    Sánchez et al.
    J.Pharmacol.Exp.Ther., 1997;283:1323
  3. Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes.
    Česen et al.
    Cell Death Des., 2013;4:e818

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Siramesine hydrochloride

There are currently no reviews for this product. Be the first to review Siramesine hydrochloride and earn rewards!

Have you used Siramesine hydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.