Siramesine hydrochloride

Key Product Details

Product Description

Siramesine hydrochloride is a high affinity σ receptor agonist (K_i values are 0.19 and 17 nM for σ₂ and σ₁ receptors, respectively). Displays anxiolytic and antidepressant effects in rodents. Also induces cell death in tumor cell lines.

Product Specifications for Siramesine hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Siramesine hydrochloride

The following data is based on the product molecular weight 491.04.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.07 mL	20.36 mL	40.73 mL
2.5 mM	0.81 mL	4.07 mL	8.15 mL
5 mM	0.41 mL	2.04 mL	4.07 mL
25 mM	0.08 mL	0.41 mL	0.81 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Sánchez The selective σ₂-ligand Lu 28-179 has potent anxiolytic-like effects in rodents. J.Pharmacol.Exp.Ther. 1997 PMID: 9400007
• Česen Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. Cell Death Des. 2013 PMID: 24091661
• Søby Lu 28-179 labels a σ₂-site in rat and human brain. Neuropharmacology. 2002 PMID: 12213263

Product Documents for Siramesine hydrochloride