Siramesine hydrochloride

Catalog # Availability Size / Price Qty
Siramesine hydrochloride | CAS No. 224177-60-0 | General Sigma Receptor Ligands
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Description: High affinity σ agonist (σ2 > σ1)

Chemical Name: 1'-[4-[1-(4-Fluorophenyl)-1H-indol-3-yl]butyl]spiro[isobenzofuran-1(3H),4'-piperidine hydrochloride

Purity: ≥98%

Product Details

Biological Activity

Siramesine hydrochloride is a high affinity σ receptor agonist (Ki values are 0.19 and 17 nM for σ2 and σ1 receptors, respectively). Displays anxiolytic and antidepressant effects in rodents. Also induces cell death in tumor cell lines.

Technical Data

Soluble to 50 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Lu 28-179 labels a σ2-site in rat and human brain.
    Søby et al.
    Neuropharmacology., 2002;43:95
  2. The selective σ2-ligand Lu 28-179 has potent anxiolytic-like effects in rodents.
    Sánchez et al.
    J.Pharmacol.Exp.Ther., 1997;283:1323
  3. Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes.
    Česen et al.
    Cell Death Des., 2013;4:e818

Product Datasheets

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