SirReal 2 (CAS 709002-46-0): R&D Systems
Catalog Number: 5457
Chemical Name: 2-[(4,6-Dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]acetamide
Biological Activity
Selective SIRT2 inhibitor (IC50 = 140 nM). Has minimal effect on SIRT1 and SIRT3-6. Increases α-tubulin acetylation levels in HeLa cells.
Technical Data
  • M.Wt:
    420.55
  • Formula:
    C22H20N4OS2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    709002-46-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.
    Rumpf et al.
    Nat.Commun., 2015;6:6263

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