Cell-permeable, selective sirtuin deacetylase inhibitor (IC50
values are 38, 68 and 131 μ
M at SIRT2, Sir2p and SIRT1 respectively) that has no effect on HDAC1 activity. Significantly decreases growth and viability of PCa and HEK293T cells in vitro
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All Tocris products are intended for laboratory research use only.
Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (sirtuin) inhibitors.
Mai et al.
Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening.
Grozinger et al.
A novel chalcone polyphenol inhibits the deacetylase activity of SIRT1 and cell growth in HEK293T cells.
Kahyo et al.
Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition?
Jung-Hynes et al.
The citations listed below are publications that use Tocris products. Selected citations for Sirtinol include:
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