Sirtinol

  ( 3 citations )    
Product Datasheet
Catalog Number:3521
Chemical Name:2-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)benzamide
Product Details
Citations (3)
Reviews
Biological Activity
Cell-permeable, selective sirtuin deacetylase inhibitor (IC50 values are 38, 68 and 131 μM at SIRT2, Sir2p and SIRT1 respectively) that has no effect on HDAC1 activity. Significantly decreases growth and viability of PCa and HEK293T cells in vitro.
Technical Data
  • M.Wt:
    394.47
  • Formula:
    C26H22N2O2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    410536-97-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Sirtinol include:

3 Citations: Showing 1 - 3
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  1. Thyroid hormone activation of retinoic acid synthesis in hypothalamic tanycytes.
    Authors: Stoney Et al.
    Glia  2016;64:425
  2. Hypoxia initiates sirtuin1-mediated vascular endothelial growth factor activation in choroidal endothelial cells through hypoxia inducible factor-2α.
    Authors: Balaiya Et al.
    Mol Vis  2012;18:114
  3. Resveratrol reverses monocrotaline-induced pulmonary vascular and cardiac dysfunction: a potential role for atrogin-1 in smooth muscle.
    Authors: Paffett Et al.
    Vascul Pharmacol  2011;56:64

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