Sirtinol

Key Product Details

Product Description

Sirtinol is a cell-permeable, selective sirtuin deacetylase inhibitor (IC₅₀ values are 38, 68 and 131 μM at SIRT2, Sir2p and SIRT1 respectively) that has no effect on HDAC1 activity. Significantly decreases growth and viability of PCa and HEK293T cells in vitro.

Product Specifications for Sirtinol

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Sirtinol

The following data is based on the product molecular weight 394.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.54 mL	12.68 mL	25.35 mL
5 mM	0.51 mL	2.54 mL	5.07 mL
10 mM	0.25 mL	1.27 mL	2.54 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 26 publications citing the usage of this product.

• Jung-Hynes Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition? J.Biol.Chem. 2009 PMID: 19075016
• Mai Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (sirtuin) inhibitors. J.Med.Chem. 2005 PMID: 16302818
• Kahyo A novel chalcone polyphenol inhibits the deacetylase activity of SIRT1 and cell growth in HEK293T cells. J.Pharmacol.Sci. 2008 PMID: 19008647
• Grozinger Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. J.Biol.Chem. 2001 PMID: 11483616

Product Documents for Sirtinol