Catalog Number: 3535
Alternate Names: ONO-5046
Chemical Name: N-{2-[({4-[(2,2-Dimethylpropanoyl)oxy]phenyl}sulfonyl)amino]benzoyl}glycine sodium salt
Biological Activity
Selective leukocyte elastase inhibitor (IC50 = 44 nM) that displays no activity at a range of other proteases. Inhibits NF-κB activation and LTB4-induced neutrophil transmigration in vitro. Significantly attenuates ischemia-induced spinal cord injury, decreases serum cytokine levels and reduces acute inflammatory lung injury in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. ONO-5046, a novel inhibitor of human neutrophil elastase.
    Kawabata et al.
    Biochem.Biophys.Res.Commun., 1991;177:814
  2. Role of neutrophil elastase in LTB4-induced neutrophil transmigration in vivo assessed with a specific inhibitor and neutrophil elastase deficient mice.
    Young et al.
    Br.J.Pharmacol., 2007;151:628
  3. Neutrophil elastase inhibitor (sivelestat) reduces the levels of inflammatory mediators by inhibiting NF-κB.
    Hagiwara et al.
    Inflamm.Res., 2009;58:198
  4. Protective effect of sivelestat sodium hydrate (ONO-5046) on ischemic spinal cord injury.
    Iwamoto et al.
    Interact.Cardiovasc.Thorac.Surg., 2009;8:606

The citations listed below are publications that use Tocris products. Selected citations for Sivelestat sodium salt include:

1 Citations: Showing 1 - 1

  1. Neutrophil protease inhibition reduces neuromyelitis optica-immunoglobulin G-induced damage in mouse brain.
    Authors: Saadoun Et al.
    J Neurosci 2012;71:323

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