Sivelestat sodium salt

Catalog # Availability Size / Price Qty
3535/10
3535/50
Sivelestat sodium salt | CAS No. 150374-95-1 | Synthetic Elastase Inhibitors
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Description: Selective leukocyte elastase inhibitor
Alternative Names: ONO-5046

Chemical Name: N-{2-[({4-[(2,2-Dimethylpropanoyl)oxy]phenyl}sulfonyl)amino]benzoyl}glycine sodium salt

Purity: ≥98%

Product Details
Citations (4)
Reviews

Biological Activity

Selective leukocyte elastase inhibitor (IC50 = 44 nM) that displays no activity at a range of other proteases. Inhibits NF-κB activation and LTB4-induced neutrophil transmigration in vitro. Significantly attenuates ischemia-induced spinal cord injury, decreases serum cytokine levels and reduces acute inflammatory lung injury in vivo.

Technical Data

M.Wt:
456.44
Formula:
C20H21N2NaO7S
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
150374-95-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Sivelestat sodium salt

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