Selective leukocyte elastase inhibitor (IC50
= 44 nM) that displays no activity at a range of other proteases. Inhibits NF-κ
B activation and LTB4
-induced neutrophil transmigration in vitro
. Significantly attenuates ischemia-induced spinal cord injury, decreases serum cytokine levels and reduces acute inflammatory lung injury in vivo
Soluble to 50 mM in DMSO
Desiccate at RT
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All Tocris products are intended for laboratory research use only.
ONO-5046, a novel inhibitor of human neutrophil elastase.
Kawabata et al.
Role of neutrophil elastase in LTB4-induced neutrophil transmigration in vivo assessed with a specific inhibitor and neutrophil elastase deficient mice.
Young et al.
Neutrophil elastase inhibitor (sivelestat) reduces the levels of inflammatory mediators by inhibiting NF-κB.
Hagiwara et al.
Protective effect of sivelestat sodium hydrate (ONO-5046) on ischemic spinal cord injury.
Iwamoto et al.
The citations listed below are publications that use Tocris products. Selected citations for Sivelestat sodium salt include:
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