SJF 1521

Tocris Bioscience | Catalog # 7261

Selective EGFR PROTAC® Degrader
Tocris Bioscience

Key Product Details

Description

Selective EGFR PROTAC® Degrader
View all Active Degraders »

Product Description

SJF 1521 is a selective EGFR PROTAC® Degrader. SJF 1521 comprises the EGFR inhibitor lapatinib (Cat. No. 6811) joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Exhibits selectivity for EGFR, including mutant forms, over HER2. Induces degradation of EGFR in OVCAR8 cells.

EGFR antibody validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF231

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Product Specifications for SJF 1521

Molecular Weight

1074.66

Formula

C57H61ClFN7O9S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(2S,4R)-1-((S)-2-(tert-Butyl)-14-(4-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl)phenoxy)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

CAS Number

2230821-40-4

PubChem ID

135157094

InChI Key

XZNORRXEBCTXPB-KHBXAZQSSA-N

SMILES

CC1=C(C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(COCCOCCOCCOC4=CC=C(C5=CC6=C(N=CN=C6NC7=CC(Cl)=C(C=C7)OCC8=CC(F)=CC=C8)C=C5)C=C4)=O)=O)O)=O)SC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 107.47 100

Preparing Stock Solutions for SJF 1521

The following data is based on the product molecular weight 1074.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.93 mL 4.65 mL 9.31 mL
5 mM 0.19 mL 0.93 mL 1.86 mL
10 mM 0.09 mL 0.47 mL 0.93 mL
50 mM 0.02 mL 0.09 mL 0.19 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for SJF 1521

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SJF 1521

For research use only

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