SJF 8240

Tocris Bioscience | Catalog # 7266

c-MET PROTAC®; also degrades exon-14-deleted c-MET
Tocris Bioscience

Key Product Details

Description

c-MET PROTAC®; also degrades exon-14-deleted c-MET
View all Active Degraders »

Product Description

SJF 8240 is a c-MET PROTAC® Degrader. Comprises MET inhibitor foretinib joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Degrades c-MET within 6 hours in vitro. Inhibits agonist-driven AKT phosphorylation and GTL16 cell proliferation (IC50 = 66.7 nM). Also degrades exon-14-deleted c-MET in Hs746T cells.

c-MET antibodies validated for Western Blot also available: Catalog # AF276 and MAB5694.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Product Specifications for SJF 8240

Molecular Weight

1106.25

Formula

C58H65F2N7O11S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-(3-Fluoro-4-((7-(3-(3-(3-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-3-oxopropoxy)propoxy)propoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

CAS Number

2230821-68-6

PubChem ID

135175904

InChI Key

SCUZPTNDZHEHLB-ZWUDBOSPSA-N

SMILES

COC1=CC2=C(N=CC=C2OC3=C(C=C(C=C3)NC(C4(C(NC5=CC=C(C=C5)F)=O)CC4)=O)F)C=C1OCCCOCCCOCCC(N[C@@H](C(C)(C)C)C(N6C[C@@H](C[C@H]6C(NCC7=CC=C(C8=C(N=CS8)C)C=C7)=O)O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 55.31 50

Preparing Stock Solutions for SJF 8240

The following data is based on the product molecular weight 1106.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 1.81 mL 9.04 mL 18.08 mL
2.5 mM 0.36 mL 1.81 mL 3.62 mL
5 mM 0.18 mL 0.90 mL 1.81 mL
25 mM 0.04 mL 0.18 mL 0.36 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product.

Product Documents for SJF 8240

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SJF 8240

For research use only

Customer Reviews for SJF 8240 (1)

5 out of 5
1 Customer Rating
5 Stars
100%
4 Stars
0%
3 Stars
0%
2 Stars
0%
1 Stars
0%

Have you used SJF 8240?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card

Customer Images

Showing  1 - 1 of 1 review Showing All
Filter By:
Clear Filters X
  • SJF 8240
    Name: Povilas Kavaliauskas
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: HSAEC1-Kt
    Verified Customer | Posted 10/24/2023
    We use this product to degrade the c-MET from HSAEC1-KT cells prior to infecting them with pathogenic fungi of our interest. We first performed a dose-response assay where we exposed the cells to different concentrations of SJF 8240 overnight in media containing 0.1% DMSO.
    SJF 8240 7266

There are no reviews that match your criteria.

Showing  1 - 1 of 1 review Showing All