SJPYT 310

Key Product Details

Product Description

SJPYT 310 is a potent and selective PXR antagonist (IC₅₀ values are 4 and 9 nM for binding and cellular activity, respectively). SJPYT 310 displays selectivity for hPXR without affecting the activity of mPXR, hCAR, hFXR, hLXRα, or hVDR. SJPYT 310 shows no toxicity.

Licensing Information

Sold under license from St. Jude Children's Research Hospital

Product Specifications for SJPYT 310

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SJPYT 310

The following data is based on the product molecular weight 464.61.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.15 mL	10.76 mL	21.52 mL
5 mM	0.43 mL	2.15 mL	4.30 mL
10 mM	0.22 mL	1.08 mL	2.15 mL
50 mM	0.04 mL	0.22 mL	0.43 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Li Design and optimization of 1 H-1,2,3-Triazole-4-carboxamides as novel, potent, and selective inverse agonists and antagonists of PXR. J.Med.Chem. 2022 PMID: 36480704
• Garcia-Maldonado Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR. Nat.Commun. 2024 PMID: 38744881

Product Documents for SJPYT 310