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SJPYT 310

Catalog #: 8839 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
8839/10
8839/50

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SJPYT 310 | CAS No. 2883814-84-2 | PXR/NR1I2
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Description: Potent and selective PXR antagonist

Chemical Name: N-[5-(1,1-Dimethylethyl)-2-[(1S)-1-methylbutoxy]phenyl]-1-(2-methoxy-5-methylphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide

Purity: ≥98%

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Biological Activity

SJPYT 310 is a potent and selective PXR antagonist (IC50 values are 4 and 9 nM for binding and cellular activity, respectively). SJPYT 310 displays selectivity for hPXR without affecting the activity of mPXR, hCAR, hFXR, hLXRα, or hVDR. SJPYT 310 shows no toxicity.

Technical Data

M.Wt:
464.61
Formula:
C27H36N4O3
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2883814-84-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from St. Jude Children's Research Hospital

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