SK 216

Catalog # Availability Size / Price Qty
6187/50
6187/10
SK 216 | CAS No. 654080-03-2 | PAI-1 Inhibitors
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Description: Plasminogen activator inhibitor-1 (PAI-1) inhibitor

Chemical Name: 2-[5-[[6-[5-(1,1-Dimethylethyl)-2-benzoxazolyl]-2-naphthalenyl]oxy]pentyl]propanedioic acid disodium salt

Purity: ≥98%

Product Details
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Biological Activity

SK 216 is a plasminogen activator inhibitor-1 (PAI-1) inhibitor. Inhibits VEGF-induced migration and tube formation in HUVECs. Also attenuates TGF-β dependent epithelial-mesenchymal transition and fibroblast to myofibroblast differentiation in vitro. Reduces size and weight of subcutaneous tumors, and inhibits metastasis and angiogenesis in vivo. Reduces bleomycin-induced pulmonary fibrosis in vivo. Orally bioavailable.

Technical Data

M.Wt:
533.52
Formula:
C29H29NO6Na2
Solubility:
Soluble to 5 mM in water with gentle warming
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
654080-03-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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