SKF 38393 hydrobromide
Chemical Name: (±)-1-Phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8-diol hydrobromide
Biological ActivitySKF 38393 hydrobromide is a prototypical D1-like dopamine receptor selective partial agonist (Ki values are 1, ~ 0.5, ~ 150, ~ 5000 and ~ 1000 nM for D1, D5, D2, D3 and D4 receptors respectively).
The technical data provided above is for guidance only.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Characterization of unconditioned behavioral effects of DA D3/D2 receptor agonists.
Geter-Douglass et al.
DA stimulation of cardiac β-adrenoceptors: the involvement of sympathetic amine transporters and the effect of SKF38393.
Habuchi et al.
Interactions of novel DArgic ligands with D1 and D2 DA receptors.
Sibley et al.
Life Sci., 1982;31:637
DA receptor pharmacology.
Seeman and Van Tol
Trends Pharmacol.Sci., 1994;15:264
Citations for SKF 38393 hydrobromide
The citations listed below are publications that use Tocris products. Selected citations for SKF 38393 hydrobromide include:
18 Citations: Showing 1 - 10
DA Receptor Subtypes Mediate Opposing Effects on Form Deprivation Myopia in Pigmented Guinea Pigs.
Authors: Zhang Et al.
Invest Ophthalmol Vis Sci 2018;59(11):4441
Posttranslational modification impact on the mechanism by which amyloid-β induces synaptic dysfunction.
Authors: Grochowska Et al.
EMBO Rep 2017;18:962
Levo-Tetrahydroberberrubine Produces Anxiolytic-Like Effects in Mice through the 5-HT 1A Receptor.
Plos One 2017;12:e0168964
OCD candidate gene SLC1A1/EAAT3 impacts basal ganglia-mediated activity and stereotypic behavior.
Proc Natl Acad Sci USA 2017;114(22):5719
DA D1 receptor activation regulates the expression of the estrogen synthesis gene aromatase B in radial glial cells.
Authors: Xing Et al.
Eur J Neurosci 2015;9:310
Endogenous 17β-OE is required for activity-dependent long-term potentiation in the striatum: interaction with the DArgic system.
Authors: Tozzi Et al.
Front Cell Neurosci 2015;9:192
DA Modulates the Activity of Sensory Hair Cells.
Authors: Toro Et al.
J Neurosci 2015;35:16494
Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3).
Authors: Polito Et al.
J Immunol 2015;2
Cocaine disrupts histamine H3 receptor modulation of DA D1 receptor signaling: σ1-D1-H3 receptor complexes as key targets for reducing cocaine's effects.
Authors: Moreno Et al.
J Neurosci 2014;34:3545
DArgic modulation of GABAergic transmission in the entorhinal cortex: concerted roles of α1 adrenoreceptors, inward rectifier K+, and T-type Ca2+ channels.
Authors: Cilz Et al.
Cereb Cortex 2014;24:3195
Diminished FoxP2 levels affect DArgic modulation of corticostriatal signaling important to song variability.
Authors: Murugan Et al.
Age-dependent regulation of synaptic connections by DA D2 receptors.
Authors: Jia Et al.
Nat Neurosci 2013;16:1627
DArgic modulation of ganglion-cell photoreceptors in rat.
Authors: Hook Et al.
D4 DA receptors modulate NR2B NMDA receptors and LTP in stratum oriens of hippocampal CA1.
Authors: Herwerth Et al.
Cereb Cortex 2012;22:1786
Stimulation of DA receptor D5 expressed on dendritic cells potentiates Th17-mediated immunity.
Authors: Prado Et al.
J Biol Chem 2012;188:3062
DArgic regulation of sleep and cataplexy in a murine model of narcolepsy.
Authors: Burgess Et al.
D1/5 receptor-mediated enhancement of LTP requires PKA, Src family kinases, and NR2B-containing NMDARs.
Identification of DA D1-D3 receptor heteromers. Indications for a role of synergistic D1-D3 receptor interactions in the striatum.
Authors: Marcellino Et al.
Front Neurosci 2008;283:26016
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