SKF 38393 hydrobromide

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SKF 38393 hydrobromide | CAS No. 20012-10-6 | Dopamine D1 and D5 Receptor Agonists
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Description: Selective D1-like agonist

Chemical Name: (±)-1-Phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8-diol hydrobromide

Purity: ≥98%

Product Details
Citations (18)
Supplemental Products

Biological Activity

SKF 38393 hydrobromide is a prototypical D1-like dopamine receptor selective partial agonist (Ki values are 1, ~ 0.5, ~ 150, ~ 5000 and ~ 1000 nM for D1, D5, D2, D3 and D4 receptors respectively).

Technical Data

Soluble to 25 mM in water with gentle warming and to 100 mM in DMSO
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Characterization of unconditioned behavioral effects of DA D3/D2 receptor agonists.
    Geter-Douglass et al.
    J.Pharmacol.Exp.Ther., 1997;283:7
  2. DA stimulation of cardiac β-adrenoceptors: the involvement of sympathetic amine transporters and the effect of SKF38393.
    Habuchi et al.
    Br.J.Pharmacol., 1997;122:1669
  3. Interactions of novel DArgic ligands with D1 and D2 DA receptors.
    Sibley et al.
    Life Sci., 1982;31:637
  4. DA receptor pharmacology.
    Seeman and Van Tol
    Trends Pharmacol.Sci., 1994;15:264

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Citations for SKF 38393 hydrobromide

The citations listed below are publications that use Tocris products. Selected citations for SKF 38393 hydrobromide include:

18 Citations: Showing 1 - 10

  1. DA Receptor Subtypes Mediate Opposing Effects on Form Deprivation Myopia in Pigmented Guinea Pigs.
    Authors: Zhang Et al.
    Invest Ophthalmol Vis Sci  2018;59(11):4441
  2. Posttranslational modification impact on the mechanism by which amyloid-β induces synaptic dysfunction.
    Authors: Grochowska Et al.
    EMBO Rep  2017;18:962
  3. Levo-Tetrahydroberberrubine Produces Anxiolytic-Like Effects in Mice through the 5-HT 1A Receptor.
    Authors: Mi
    Plos One  2017;12:e0168964
  4. OCD candidate gene SLC1A1/EAAT3 impacts basal ganglia-mediated activity and stereotypic behavior.
    Authors: Zike
    Proc Natl Acad Sci USA  2017;114(22):5719
  5. DA D1 receptor activation regulates the expression of the estrogen synthesis gene aromatase B in radial glial cells.
    Authors: Xing Et al.
    Eur J Neurosci  2015;9:310
  6. Endogenous 17β-OE is required for activity-dependent long-term potentiation in the striatum: interaction with the DArgic system.
    Authors: Tozzi Et al.
    Front Cell Neurosci  2015;9:192
  7. DA Modulates the Activity of Sensory Hair Cells.
    Authors: Toro Et al.
    J Neurosci  2015;35:16494
  8. Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3).
    Authors: Polito Et al.
    J Immunol  2015;2
  9. Cocaine disrupts histamine H3 receptor modulation of DA D1 receptor signaling: σ1-D1-H3 receptor complexes as key targets for reducing cocaine's effects.
    Authors: Moreno Et al.
    J Neurosci  2014;34:3545
  10. DArgic modulation of GABAergic transmission in the entorhinal cortex: concerted roles of α1 adrenoreceptors, inward rectifier K+, and T-type Ca2+ channels.
    Authors: Cilz Et al.
    Cereb Cortex  2014;24:3195


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