Catalog Number: 0922
Chemical Name: (±)-1-Phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8-diol hydrobromide
Biological Activity
Prototypical D1-like dopamine receptor selective partial agonist (Ki values are 1, ~ 0.5, ~ 150, ~ 5000 and ~ 1000 nM for D1, D5, D2, D3 and D4 receptors respectively).
Technical Data
  • M.Wt:
    336.23
  • Formula:
    C16H17NO2.HBr
  • Solubility:
    Soluble to 25 mM in water with gentle warming and to 25 mM in ethanol with gentle warming
  • Purity:
    >99%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    20012-10-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Dopamine stimulation of cardiac β-adrenoceptors: the involvement of sympathetic amine transporters and the effect of SKF38393.
    Habuchi et al.
    Br.J.Pharmacol., 1997;122:1669
  2. Characterization of unconditioned behavioral effects of dopamine D3/D2 receptor agonists.
    Geter-Douglass et al.
    J.Pharmacol.Exp.Ther., 1997;283:7
  3. Dopamine receptor pharmacology.
    Seeman and Van Tol
    Trends Pharmacol.Sci., 1994;15:264
  4. Interactions of novel dopaminergic ligands with D1 and D2 dopamine receptors.
    Sibley et al.
    Life Sci., 1982;31:637
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SKF 38393 hydrobromide include:

12 Citations: Showing 1 - 10
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  1. Levo-Tetrahydroberberrubine Produces Anxiolytic-Like Effects in Mice through the 5-HT 1A Receptor.
    Authors: Mi
    Plos One 2017;12:e0168964
  2. OCD candidate gene SLC1A1/EAAT3 impacts basal ganglia-mediated activity and stereotypic behavior.
    Authors: Zike
    Proc Natl Acad Sci USA 2017;114(22):5719
  3. Dopamine D1 receptor activation regulates the expression of the estrogen synthesis gene aromatase B in radial glial cells.
    Authors: Xing Et al.
    Eur J Neurosci 2015;9:310
  4. Endogenous 17β-estradiol is required for activity-dependent long-term potentiation in the striatum: interaction with the dopaminergic system.
    Authors: Tozzi Et al.
    Front Cell Neurosci 2015;9:192
  5. Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3).
    Authors: Polito Et al.
    J Immunol 2015;2
  6. Cocaine disrupts histamine H3 receptor modulation of dopamine D1 receptor signaling: σ1-D1-H3 receptor complexes as key targets for reducing cocaine's effects.
    Authors: Moreno Et al.
    J Neurosci 2014;34:3545
  7. Diminished FoxP2 levels affect dopaminergic modulation of corticostriatal signaling important to song variability.
    Authors: Murugan Et al.
    Neuron 2013;80:1464
  8. Age-dependent regulation of synaptic connections by dopamine D2 receptors.
    Authors: Jia Et al.
    Nat Neurosci 2013;16:1627
  9. Dopaminergic modulation of ganglion-cell photoreceptors in rat.
    Authors: Hook Et al.
    Eneuro 2012;35:507
  10. Stimulation of dopamine receptor D5 expressed on dendritic cells potentiates Th17-mediated immunity.
    Authors: Prado Et al.
    J Biol Chem 2012;188:3062
  11. Dopaminergic regulation of sleep and cataplexy in a murine model of narcolepsy.
    Authors: Burgess Et al.
    Sleep 2010;33:1295
  12. Identification of dopamine D1-D3 receptor heteromers. Indications for a role of synergistic D1-D3 receptor interactions in the striatum.
    Authors: Marcellino Et al.
    Front Neurosci 2008;283:26016
Expand to show all 12 Citations

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