SKF 83822 hydrobromide
Chemical Name: 6-Chloro-2,3,4,5-tetrahydro-1-(3-methylphenyl)-3-(2-propenyl)-1H-3-benzazepine-7,8-diol hydrobromide
Biological ActivityHigh affinity, selective dopamine D1-like receptor agonist. Ki values are 3.2, 3.1, 186, 66, 335, 1167, 1251 and 1385 nM at recombinant D1, D5, D2, D3, D4, 5-HT2A, α1A and α1B receptors respectively. Stimulates adenylyl cyclase (EC50 = 65 nM) but not phosphoinositide hydrolysis. Induces extreme arousal and hyperlocomotion following subcutaneous administration in monkeys.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Evidence for a distinct D1-like DA receptor that couples to activation of phosphoinositide metabolism in brain.
Undie et al.
Aberrant behavioural effects of a DA D1 receptor antagonist and agonist in monkeys: evidence of uncharted DA D1 receptor actions.
Peacock and Gerlach
SK&F 83822 distinguishes adenylyl cyclase from phospholipase C-coupled D1-like receptors: behavioural topography.
O'Sullivan et al.
Citations for SKF 83822 hydrobromide
The citations listed below are publications that use Tocris products. Selected citations for SKF 83822 hydrobromide include:
3 Citations: Showing 1 - 3
DA in the dorsal hippocampus impairs the late consolidation of cocaine-associated memory.
Authors: Kramar Et al.
J Neurosci 2014;39:1645
Ketogenic diet improves core symptoms of autism in BTBR mice.
Authors: Ruskin Et al.
PLoS One 2013;8:e65021
CODA-RET reveals functional selectivity as a result of GPCR heteromerization.
Authors: Urizar Et al.
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for SKF 83822 hydrobromide
There are currently no reviews for this product. Be the first to review SKF 83822 hydrobromide and earn rewards!
Have you used SKF 83822 hydrobromide?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image