Catalog Number: 2075
Chemical Name: 6-Chloro-2,3,4,5-tetrahydro-1-(3-methylphenyl)-3-(2-propenyl)-1H-3-benzazepine-7,8-diol hydrobromide
Biological Activity
High affinity, selective dopamine D1-like receptor agonist. Ki values are 3.2, 3.1, 186, 66, 335, 1167, 1251 and 1385 nM at recombinant D1, D5, D2, D3, D4, 5-HT2A, α1A and α1B receptors respectively. Stimulates adenylyl cyclase (EC50 = 65 nM) but not phosphoinositide hydrolysis. Induces extreme arousal and hyperlocomotion following subcutaneous administration in monkeys.
Technical Data
  • M.Wt:
    424.76
  • Formula:
    C20H22ClNO2.HBr
  • Solubility:
    Soluble to 10 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    74115-10-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Evidence for a distinct D1-like dopamine receptor that couples to activation of phosphoinositide metabolism in brain.
    Undie et al.
    J.Neurochem., 1994;62:2045
  2. Aberrant behavioural effects of a dopamine D1 receptor antagonist and agonist in monkeys: evidence of uncharted dopamine D1 receptor actions.
    Peacock and Gerlach
    Biol.Psychiatry, 2001;50:501
  3. SK&F 83822 distinguishes adenylyl cyclase from phospholipase C-coupled D1-like receptors: behavioural topography.
    O'Sullivan et al.
    Eur.J.Pharmacol., 2004;486:273
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SKF 83822 hydrobromide include:

3 Citations: Showing 1 - 3
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  1. Dopamine in the dorsal hippocampus impairs the late consolidation of cocaine-associated memory.
    Authors: Kramar Et al.
    J Neurosci 2014;39:1645
  2. Ketogenic diet improves core symptoms of autism in BTBR mice.
    Authors: Ruskin Et al.
    PLoS One 2013;8:e65021
  3. CODA-RET reveals functional selectivity as a result of GPCR heteromerization.
    Authors: Urizar Et al.
    Neuropsychopharmacology 2011;7:624

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