SKF 83822 hydrobromide

  ( 3 citations )    
Product Datasheet
Catalog Number:2075
Chemical Name:6-Chloro-2,3,4,5-tetrahydro-1-(3-methylphenyl)-3-(2-propenyl)-1H-3-benzazepine-7,8-diol hydrobromide
Product Details
Citations (3)
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Biological Activity
High affinity, selective dopamine D1-like receptor agonist. Ki values are 3.2, 3.1, 186, 66, 335, 1167, 1251 and 1385 nM at recombinant D1, D5, D2, D3, D4, 5-HT2A, α1A and α1B receptors respectively. Stimulates adenylyl cyclase (EC50 = 65 nM) but not phosphoinositide hydrolysis. Induces extreme arousal and hyperlocomotion following subcutaneous administration in monkeys.
Technical Data
  • M.Wt:
    424.76
  • Formula:
    C20H22ClNO2.HBr
  • Solubility:
    Soluble to 10 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    74115-10-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for SKF 83822 hydrobromide include:

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  1. Dopamine in the dorsal hippocampus impairs the late consolidation of cocaine-associated memory.
    Authors: Kramar Et al.
    J Neurosci  2014;39:1645
  2. Ketogenic diet improves core symptoms of autism in BTBR mice.
    Authors: Ruskin Et al.
    PLoS One  2013;8:e65021
  3. CODA-RET reveals functional selectivity as a result of GPCR heteromerization.
    Authors: Urizar Et al.
    Neuropsychopharmacology  2011;7:624

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