High affinity, selective dopamine D
-like receptor agonist. K
values are 3.2, 3.1, 186, 66, 335, 1167, 1251 and 1385 nM at recombinant D
receptors respectively. Stimulates adenylyl cyclase (EC
= 65 nM) but not phosphoinositide hydrolysis. Induces extreme arousal and hyperlocomotion following subcutaneous administration in monkeys.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Evidence for a distinct D 1-like dopamine receptor that couples to activation of phosphoinositide metabolism in brain.
Undie et al.
Aberrant behavioural effects of a dopamine D1 receptor antagonist and agonist in monkeys: evidence of uncharted dopamine D1 receptor actions.
Peacock and Gerlach
SK&F 83822 distinguishes adenylyl cyclase from phospholipase C-coupled D1-like receptors: behavioural topography.
O'Sullivan et al.
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