SKF 83822 hydrobromide
Chemical Name: 6-Chloro-2,3,4,5-tetrahydro-1-(3-methylphenyl)-3-(2-propenyl)-1H-3-benzazepine-7,8-diol hydrobromide
Biological ActivitySKF 83822 hydrobromide is a high affinity, selective dopamine D1-like receptor agonist. Ki values are 3.2, 3.1, 186, 66, 335, 1167, 1251 and 1385 nM at recombinant D1, D5, D2, D3, D4, 5-HT2A, α1A and α1B receptors respectively. Stimulates adenylyl cyclase (EC50 = 65 nM) but not phosphoinositide hydrolysis. Induces extreme arousal and hyperlocomotion following subcutaneous administration in monkeys.
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Evidence for a distinct D1-like DA receptor that couples to activation of phosphoinositide metabolism in brain.
Undie et al.
Aberrant behavioural effects of a DA D1 receptor antagonist and agonist in monkeys: evidence of uncharted DA D1 receptor actions.
Peacock and Gerlach
SK&F 83822 distinguishes adenylyl cyclase from phospholipase C-coupled D1-like receptors: behavioural topography.
O'Sullivan et al.
Citations for SKF 83822 hydrobromide
The citations listed below are publications that use Tocris products. Selected citations for SKF 83822 hydrobromide include:
3 Citations: Showing 1 - 3
DA in the dorsal hippocampus impairs the late consolidation of cocaine-associated memory.
Authors: Kramar Et al.
J Neurosci 2014;39:1645
Ketogenic diet improves core symptoms of autism in BTBR mice.
Authors: Ruskin Et al.
PLoS One 2013;8:e65021
CODA-RET reveals functional selectivity as a result of GPCR heteromerization.
Authors: Urizar Et al.
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