SKF 91488 dihydrochloride

Key Product Details

Product Description

SKF 91488 dihydrochloride is a homolog of dimaprit (Cat. No. 0506); strong inhibitor of histamine N-methyltransferase. Exhibits no histamine agonist activity.

Product Specifications for SKF 91488 dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SKF 91488 dihydrochloride

The following data is based on the product molecular weight 248.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	5.37 mL	26.86 mL	53.72 mL
3.75 mM	1.07 mL	5.37 mL	10.74 mL
7.5 mM	0.54 mL	2.69 mL	5.37 mL
37.5 mM	0.11 mL	0.54 mL	1.07 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Ohuri Histamine N-methyl transferase controls the contractile response of guinea pig trachea to histamine. J.Pharmacol.Exp.Ther. 1992 PMID: 1534842
• Beaven and Shaff New inhibitors of histamine N-methyl-transferase. Biochem.Pharmacol. 1979 PMID: 34400
• Beaven and Shaff Inhibition of histamine methylation in vivo by the dimaprit analog SKF compound 91488. Agents Actions 1979 PMID: 161853
• Aiello Effects of two histamine-N-methyltransferase inhibitors, SKF 91488 and BW 301U, in rodent antinociception. Naunyn Schmiedebergs Arch.Pharmacol. 1997 PMID: 9089666

Product Documents for SKF 91488 dihydrochloride