Catalog Number: 0512
Chemical Name: 4-(N,N-Dimethylamino)butylisothiourea dihydrochloride
Biological Activity
Homolog of dimaprit (Cat. No. 0506); strong inhibitor of histamine N-methyltransferase. Exhibits no histamine agonist activity.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 75 mM in DMSO
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Effects of two histamine-N-methyltransferase inhibitors, SKF 91488 and BW 301U, in rodent antinociception.
    Aiello et al.
    Naunyn Schmiedebergs Arch.Pharmacol., 1997;355:354
  2. New inhibitors of histamine N-methyl-transferase.
    Beaven and Shaff
    Biochem.Pharmacol., 1979;28:183
  3. Inhibition of histamine methylation in vivo by the dimaprit analog SKF compound 91488.
    Beaven and Shaff
    Agents Actions, 1979;9:455
  4. Histamine N-methyl transferase controls the contractile response of guinea pig trachea to histamine.
    Ohuri et al.
    J.Pharmacol.Exp.Ther., 1992;261:1268
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