Dimaprit dihydrochloride
Chemical Name: S-(3-Dimethylaminopropyl)isothiourea dihydrochloride
Purity: ≥99%
Biological Activity
Dimaprit dihydrochloride is a selective H2 agonist with central effects upon systemic administration. Also inhibits nNOS (IC50 = 49 μM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Influence of different histamine receptor agonists and antagonists on apomorphine-induced licking behavior in rats.
Farzin and Attarzadeh
Eur.J.Pharmacol., 2000;404:169 -
Dimaprit-(S-[3-(N,N-dimethylamino)propyl]isothiourea) a highly specific histamine H2-receptor agonist. Part 2. Structure activity considerations.
Durant et al.
Agents Actions, 1977;7:39 -
Nitric oxide synthase inhibition by dimaprit and dimaprit analogues.
Paquay et al.
Br.J.Pharmacol., 1999;127:331 -
Dimaprit-(S-[3-(N,N-dimethylamino)propyl]isothiourea)-a highly specific histamine H2-receptor agonist. Part 1. Pharmacology.
Parsons et al.
Agents Actions, 1977;7:31
Product Datasheets
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Citations for Dimaprit dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Dimaprit dihydrochloride include:
3 Citations: Showing 1 - 3
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Roles of histamine on the expression of aldehyde dehydrogenase 1 in endometrioid adenocarcinoma cell line.
Authors: Wang Et al.
J Immunol 2014;3:1126
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Cutting edge: histamine is required for IL-4-driven eosinophilic allergic responses.
Authors: Swartzendruber Et al.
Stem Cells Transl Med 2012;188:536
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Stimulation of mucosal secretion by lubipro. (SPI-0211) in guinea pig small intestine and colon.
Authors: Fei Et al.
Am J Physiol Gastrointest Liver Physiol 2009;296:G823
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