Catalog Number: 0506
Chemical Name: S-(3-Dimethylaminopropyl)isothiourea dihydrochloride
Biological Activity
Selective H2 agonist with central effects upon systemic administration. Also inhibits nNOS (IC50 = 49 μM).
Technical Data
  • M.Wt:
    234.19
  • Formula:
    C6H15N3S.2HCl
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    23256-33-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Influence of different histamine receptor agonists and antagonists on apomorphine-induced licking behavior in rats.
    Farzin and Attarzadeh
    Eur.J.Pharmacol., 2000;404:169
  2. Dimaprit-(S-[3-(N,N-dimethylamino)propyl]isothiourea) a highly specific histamine H2-receptor agonist. Part 2. Structure activity considerations.
    Durant et al.
    Agents Actions, 1977;7:39
  3. Nitric oxide synthase inhibition by dimaprit and dimaprit analogues.
    Paquay et al.
    Br.J.Pharmacol., 1999;127:331
  4. Dimaprit-(S-[3-(N,N-dimethylamino)propyl]isothiourea)-a highly specific histamine H2-receptor agonist. Part 1. Pharmacology.
    Parsons et al.
    Agents Actions, 1977;7:31
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Dimaprit dihydrochloride include:

2 Citations: Showing 1 - 2
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  1. Roles of histamine on the expression of aldehyde dehydrogenase 1 in endometrioid adenocarcinoma cell line.
    Authors: Wang Et al.
    J Immunol 2014;3:1126
  2. Cutting edge: histamine is required for IL-4-driven eosinophilic allergic responses.
    Authors: Swartzendruber Et al.
    Stem Cells Transl Med 2012;188:536

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