SKF 96365 hydrochloride

Catalog # Availability Size / Price Qty
1147/10
1147/50
SKF 96365 hydrochloride | CAS No. 130495-35-1 | TRPC Channel Blockers
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Description: TRPC channel blocker; also inhibits store-operated Ca2+ entry

Chemical Name: 1-[2-(4-Methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl-1H-imidazole hydrochloride

Purity: ≥99%

Product Details
Citations (14)
Reviews (1)

Biological Activity

Store-operated Ca2+ entry (SOCE) inhibitor that inhibits STIM1. Also blocks TRPC channels, voltage-gated Ca2+ channels and potassium channels.

Technical Data

M.Wt:
402.92
Formula:
C22H26N2O3.HCl
Solubility:
Soluble to 20 mM in water with gentle warming
Purity:
≥99%
Storage:
Store at RT
CAS No:
130495-35-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for SKF 96365 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for SKF 96365 hydrochloride include:

14 Citations: Showing 1 - 10

  1. Peptide/Receptor Co-evolution Explains the Lipolytic Function of the Neuropeptide TLQP-21.
    Authors: Sahu Et al.
    Cell Rep  2019;28:2567
  2. mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways.
    Authors: Kubota Et al.
    PLoS One  2014;9:e106316
  3. Contribution of TRPC3 to store-operated calcium entry and inflammatory transductions in primary nociceptors.
    Authors: Alkhani Et al.
    Proc Natl Acad Sci U S A  2014;10:43
  4. Activation of ERK1/2 by store-operated calcium entry in rat parotid acinar cells.
    Authors: Soltoff and Lannon
    PLoS One  2013;8:e72881
  5. Calcium release-dependent actin flow in the leading process mediates axophilic migration.
    Authors: Hutchins Et al.
    Biochem J  2013;33:11361
  6. Substance P modulation of TRPC3/7 channels improves respiratory rhythm regularity and ICAN-dependent pacemaker activity.
    Authors: Ben-Mabrouk and Tryba
    Mol Pain  2010;31:1219
  7. Kisspeptin directly excites anorexigenic proopiomelanocortin neurons but inhibits orexigenic neuropeptide Y cells by an indirect synaptic mechanism.
    Authors: Fu and Pol
    J Neurosci  2010;30:10205
  8. Stress-induced switch in Numb isoforms enhances Notch-dependent expression of subtype-specific transient receptor potential channel.
    Authors: Kyriazis Et al.
    J Biol Chem  2010;285:6811
  9. Calcium homeostasis and cone signaling are regulated by interactions between calcium stores and plasma membrane ion channels.
    Authors: Szikra Et al.
    PLoS One  2009;4:e6723
  10. Functional coupling between mGluR1 and Cav3.1 T-type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines.
    Authors: Hildebrand Et al.
    J Neurosci  2009;29:9668

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a Store-operated channel blocker
By Anonymous on 05/02/2018
Application: Species: Human

SKF96365 at 20 microM blocks intracellular calcium influx through a store-operated channel in microglia culture.


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