Catalog Number: 1147
Chemical Name: 1-[2-(4-Methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl-1H-imidazole hydrochloride
Biological Activity
Store-operated Ca2+ entry (SOCE) inhibitor that inhibits STIM1. Also blocks TRPC channels, voltage-gated Ca2+ channels and potassium channels.
Technical Data
  • M.Wt:
    402.92
  • Formula:
    C22H26N2O3.HCl
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    130495-35-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. STIM and Orai: the long-awaited constituents of store-operated calcium entry.
    Varnai et al.
    TiPS, 2009;30:118
  2. The transient receptor potential channel antagonist SKF96365 is a potent blocker of low-voltage-activated T-type calcium channels.
    Singh et al.
    Br.J.Pharmacol., 2010;160:1464
  3. SK&F96365, a novel inhibitor of receptor-mediated calcium entry.
    Merritt et al.
    Biochem.J., 1990;271:515
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SKF 96365 hydrochloride include:

13 Citations: Showing 1 - 10
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  1. mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways.
    Authors: Kubota Et al.
    PLoS One 2014;9:e106316
  2. Contribution of TRPC3 to store-operated calcium entry and inflammatory transductions in primary nociceptors.
    Authors: Alkhani Et al.
    Proc Natl Acad Sci U S A 2014;10:43
  3. Activation of ERK1/2 by store-operated calcium entry in rat parotid acinar cells.
    Authors: Soltoff and Lannon
    PLoS One 2013;8:e72881
  4. Calcium release-dependent actin flow in the leading process mediates axophilic migration.
    Authors: Hutchins Et al.
    Biochem J 2013;33:11361
  5. Substance P modulation of TRPC3/7 channels improves respiratory rhythm regularity and ICAN-dependent pacemaker activity.
    Authors: Ben-Mabrouk and Tryba
    Mol Pain 2010;31:1219
  6. Kisspeptin directly excites anorexigenic proopiomelanocortin neurons but inhibits orexigenic neuropeptide Y cells by an indirect synaptic mechanism.
    Authors: Fu and Pol
    J Neurosci 2010;30:10205
  7. Stress-induced switch in Numb isoforms enhances Notch-dependent expression of subtype-specific transient receptor potential channel.
    Authors: Kyriazis Et al.
    J Biol Chem 2010;285:6811
  8. Calcium homeostasis and cone signaling are regulated by interactions between calcium stores and plasma membrane ion channels.
    Authors: Szikra Et al.
    PLoS One 2009;4:e6723
  9. Functional coupling between mGluR1 and Cav3.1 T-type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines.
    Authors: Hildebrand Et al.
    J Neurosci 2009;29:9668
  10. Dendritic glutamate release produces autocrine activation of mGluR1 in cerebellar Purkinje cells.
    Authors: Shin Et al.
    J Neuroinflammation 2008;105:746
  11. Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons.
    Authors: Huang Et al.
    J Neurosci 2004;24:4551
  12. Nitric oxide co-ordinates the activities of the capacitative and non-capacitative Ca2+-entry pathways regulated by vasopressin.
    Authors: Moneer Et al.
    Eur J Neurosci 2003;370:439
  13. NAADP+ initiates the Ca2+ response during fertilization of starfish oocytes.
    Authors: Lim Et al.
    FASEB J 2001;15:2257
Expand to show all 13 Citations

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