SKF 96365 hydrochloride

Tocris Bioscience | Catalog # 1147

TRPC channel inhibitor; also inhibits store-operated Ca2+ entry
Tocris Bioscience

Key Product Details

Description

TRPC channel inhibitor; also inhibits store-operated Ca2+ entry
View all TRPC Channel Blockers »

Product Description

SKF 96365 hydrochloride is a store-operated Ca2+ entry (SOCE) inhibitor that inhibits STIM1. Also blocks TRPC channels, voltage-gated Ca2+ channels and potassium channels.

Product Specifications for SKF 96365 hydrochloride

Molecular Weight

402.92

Formula

C22H26N2O3.HCl

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

1-[2-(4-Methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl-1H-imidazole hydrochloride

CAS Number

130495-35-1

PubChem ID

104955

InChI Key

FWLPKVQUECFKSW-UHFFFAOYSA-N

SMILES

Cl.COC1=CC=C(CCCOC(CN2C=CN=C2)C2=CC=C(OC)C=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 8.06 20 with gentle warming

Preparing Stock Solutions for SKF 96365 hydrochloride

The following data is based on the product molecular weight 402.92.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 12.41 mL 62.05 mL 124.09 mL
1 mM 2.48 mL 12.41 mL 24.82 mL
2 mM 1.24 mL 6.20 mL 12.41 mL
10 mM 0.25 mL 1.24 mL 2.48 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 31 publications citing the usage of this product.

Product Documents for SKF 96365 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SKF 96365 hydrochloride

For research use only

Related Research Areas

Ion Channels and Regulators

Citations for SKF 96365 hydrochloride

Customer Reviews for SKF 96365 hydrochloride (3)

4.7 out of 5
3 Customer Ratings
5 Stars
67%
4 Stars
33%
3 Stars
0%
2 Stars
0%
1 Stars
0%

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Showing  1 - 3 of 3 reviews Showing All
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  • It can inhibit TRPC1 channel
    Name: Yuyang Sun
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: HSG
    Verified Customer | Posted 05/30/2022
    Used SKF to test TRPC1 channel; it can inhibit the Tg induced SOCE entry.
    SKF 96365 hydrochloride 1147
  • Tested for store operated calcium entry inhibiting activity
    Name: ANANTH KUMAR KAMMALA
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Mast cells LAD2
    Verified Customer | Posted 01/30/2021
    SKF96365 HCL was used to study the Invitro Calcium mobilization assay, cytokine assay in human mast cells (LAD2), and Invivo mast cell-dependent inflammation studies. SKF96365 at a concentration of 30,50 and 100uM has inhibited the calcium mobilization via the MRGPRX2 pathway and reduced the inflammation in mast cell dependent invivo paw edema and rosacea experiments. SKF965365 HCL is the best compound to study the store-operated calcium entry assays.
    SKF 96365 hydrochloride 1147
  • a Store-operated channel blocker
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: microglia
    Verified Customer | Posted 05/02/2018
    SKF96365 at 20 microM blocks intracellular calcium influx through a store-operated channel in microglia culture.

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