SKF 96365 hydrochloride
Chemical Name: 1-[2-(4-Methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl-1H-imidazole hydrochloride
Biological ActivitySKF 96365 hydrochloride is a store-operated Ca2+ entry (SOCE) inhibitor that inhibits STIM1. Also blocks TRPC channels, voltage-gated Ca2+ channels and potassium channels.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
STIM and Orai: the long-awaited constituents of store-operated calcium entry.
Varnai et al.
The transient receptor potential channel antagonist SKF96365 is a potent blocker of low-voltage-activated T-type calcium channels.
Singh et al.
SK&F96365, a novel inhibitor of receptor-mediated calcium entry.
Merritt et al.
Citations for SKF 96365 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for SKF 96365 hydrochloride include:
14 Citations: Showing 1 - 10
Peptide/Receptor Co-evolution Explains the Lipolytic Function of the Neuropeptide TLQP-21.
Authors: Sahu Et al.
Cell Rep 2019;28:2567
mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways.
Authors: Kubota Et al.
PLoS One 2014;9:e106316
Contribution of TRPC3 to store-operated calcium entry and inflammatory transductions in primary nociceptors.
Authors: Alkhani Et al.
Proc Natl Acad Sci U S A 2014;10:43
Activation of ERK1/2 by store-operated calcium entry in rat parotid acinar cells.
Authors: Soltoff and Lannon
PLoS One 2013;8:e72881
Calcium release-dependent actin flow in the leading process mediates axophilic migration.
Authors: Hutchins Et al.
Biochem J 2013;33:11361
Substance P modulation of TRPC3/7 channels improves respiratory rhythm regularity and ICAN-dependent pacemaker activity.
Authors: Ben-Mabrouk and Tryba
Mol Pain 2010;31:1219
Kisspeptin directly excites anorexigenic proopiomelanocortin neurons but inhibits orexigenic neuropeptide Y cells by an indirect synaptic mechanism.
Authors: Fu and Pol
J Neurosci 2010;30:10205
Stress-induced switch in Numb isoforms enhances Notch-dependent expression of subtype-specific transient receptor potential channel.
Authors: Kyriazis Et al.
J Biol Chem 2010;285:6811
Calcium homeostasis and cone signaling are regulated by interactions between calcium stores and plasma membrane ion channels.
Authors: Szikra Et al.
PLoS One 2009;4:e6723
Functional coupling between mGluR1 and Cav3.1 T-type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines.
Authors: Hildebrand Et al.
J Neurosci 2009;29:9668
Dendritic glutamate release produces autocrine activation of mGluR1 in cerebellar Purkinje cells.
Authors: Shin Et al.
J Neuroinflammation 2008;105:746
Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons.
Authors: Huang Et al.
J Neurosci 2004;24:4551
Nitric oxide co-ordinates the activities of the capacitative and non-capacitative Ca2+-entry pathways regulated by vasopressin.
Authors: Moneer Et al.
Eur J Neurosci 2003;370:439
NAADP+ initiates the Ca2+ response during fertilization of starfish oocytes.
Authors: Lim Et al.
FASEB J 2001;15:2257
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SKF96365 HCL was used to study the Invitro Calcium mobilization assay, cytokine assay in human mast cells (LAD2), and Invivo mast cell-dependent inflammation studies. SKF96365 at a concentration of 30,50 and 100uM has inhibited the calcium mobilization via the MRGPRX2 pathway and reduced the inflammation in mast cell dependent invivo paw edema and rosacea experiments. SKF965365 HCL is the best compound to study the store-operated calcium entry assays.
SKF96365 at 20 microM blocks intracellular calcium influx through a store-operated channel in microglia culture.