SKLB-11A

Key Product Details

Product Description

SKLB-11A is a potent and selective allosteric activator of SIRT3 (Kd = 4.7 μM), enhancing its deacetylation activity (EC₅₀ = 22 μM). SKLB-11A showed no binding to SIRT5 or SIRT6, and low binding affinity for SIRT1 and SIRT2 (Kd values exceeded 200 μM, 40 times lower than its affinity for SIRT3).

In vitro and in vivo, SKLB-11A induces autophagy, leading to cardioprotective efficacy.

Product Specifications for SKLB-11A

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SKLB-11A

The following data is based on the product molecular weight 350.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	14.27 mL	71.36 mL	142.71 mL
1 mM	2.85 mL	14.27 mL	28.54 mL
2 mM	1.43 mL	7.14 mL	14.27 mL
10 mM	0.29 mL	1.43 mL	2.85 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Zhang Unraveling small molecule-mediated sirtuin 3 activation at a distinct binding site for cardioprotective therapies. ACS Cent.Sci. 2025 PMID: 40454347

Product Documents for SKLB-11A