SL 0101-1

Catalog # Availability Size / Price Qty
2250/1
SL 0101-1 | CAS No. 77307-50-7 | RSK Inhibitors
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Description: Selective ribosomal S6 kinase (RSK) inhibitor

Chemical Name: 3-[(3,4-Di-O-acetyl-6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydro-2-(4-hydroxyphenyl)-4H-1benzopyran-4-one

Purity: ≥95%

Product Details
Citations (7)
Reviews

Biological Activity

Selective inhibitor of ribosomal S6 kinase (RSK) (IC50 = 89 nM for RSK2). Does not inhibit upstream kinases such as MEK, Raf and PKC. Inhibits the growth of MCF-7 human breast cancer cells with no effect on the normal breast cell line.

Technical Data

M.Wt:
516.46
Formula:
C25H24O12
Solubility:
Soluble to 20 mM in ethanol and to 10 mM in DMSO
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
77307-50-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The selectivity of protein kinase inhibitors: a further update.
    Bain et al.
    Biochem.J., 2007;408:297
  2. RSK phosphorylates SOS1 creating 14-3-3-docking sites and negatively regulating MAPK activation.
    Saha et al.
    Biochem.J., 2012;447:159
  3. Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation.
    Smith et al.
    Cancer Res., 2005;65:1027
  4. ERK1/2 regulates ANG II-dependent cell proliferation via cytoplasmic activation of RSK2 and nuclear activation of elk1.
    Godeny and Sayeski
    Am.J.Cell.Physiol., 2006;291:1308

Product Datasheets

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