Chemical Name: 3-[(3,4-Di-O-acetyl-6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydro-2-(4-hydroxyphenyl)-4H-1benzopyran-4-one
Biological ActivitySL 0101-1 is a selective inhibitor of ribosomal S6 kinase (RSK) (IC50 = 89 nM for RSK2). Does not inhibit upstream kinases such as MEK, Raf and PKC. Inhibits the growth of MCF-7 human breast cancer cells with no effect on the normal breast cell line.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The selectivity of protein kinase inhibitors: a further update.
Bain et al.
RSK phosphorylates SOS1 creating 14-3-3-docking sites and negatively regulating MAPK activation.
Saha et al.
Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation.
Smith et al.
Cancer Res., 2005;65:1027
ERK1/2 regulates ANG II-dependent cell proliferation via cytoplasmic activation of RSK2 and nuclear activation of elk1.
Godeny and Sayeski
Citations for SL 0101-1
The citations listed below are publications that use Tocris products. Selected citations for SL 0101-1 include:
7 Citations: Showing 1 - 7
Kinome profiling reveals breast cancer heterogeneity and identifies targeted therapeutic opportunities for triple negative breast cancer.
Authors: Al-Ejeh Et al.
J Biol Chem 2014;5:3145
RSK2 protein suppresses integrin activation and fibronectin matrix assembly and promotes cell migration.
Authors: Gawecka Et al.
J Biol Chem 2012;287:43424
Involvement of polo-like kinase 1 (Plk1) in mitotic arrest by inhibition of mitogen-activated protein kinase-extracellular signal-regulated kinase-ribosomal S6 kinase 1 (MEK-ERK-RSK1) cascade.
Authors: Li Et al.
PLoS One 2012;287:15923
PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma.
Authors: Gawecka Et al.
Int J Cancer 2012;131:1556
Regulatory effects of ribosomal S6 kinase 1 (RSK1) in IFNλ signaling.
Authors: Kroczynska Et al.
J Biol Chem 2011;286:1147
β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons.
Authors: Meitzen Et al.
J Neurochem 2011;116:984
Disassembly of shank and homer synaptic clusters is driven by soluble beta-amyloid(1-40) through divergent NMDAR-dependent signalling pathways.
Authors: Roselli Et al.
PLoS One 2009;4:e6011
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