SLV 320

Tocris Bioscience | Catalog # 3344

Potent and selective A1 antagonist
Tocris Bioscience
Discontinued Product
3344 has been discontinued. View all Adenosine A1 Receptor Antagonists products.

Key Product Details

Description

Potent and selective A1 antagonist
View all Adenosine A1 Receptor Antagonists »

Product Description

SLV 320 is a potent and selective adenosine A1 receptor antagonist (Ki values are 1, 200, 398 and 3981 nM at human A1, A3, A2A and A2B receptors respectively). Suppresses cardiac fibrosis and attenuates albuminuria, without effect on blood pressure in animal models of chronic renal failure. Orally active.

Product Specifications for SLV 320

Molecular Weight

308.38

Formula

C18H20N4O

Storage

Store at -20°C

Purity

≥99% (HPLC)

Chemical Name

trans-4-[(2-Phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexanol

CAS Number

251945-92-3

PubChem ID

9953065

InChI Key

RBZNJGHIKXAKQE-UHFFFAOYSA-N

SMILES

O[C@@H](CC4)CC[C@H]4NC1=C2C(NC=C2)=NC(C3=CC=CC=C3)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.84 100
Ethanol 15.42 50

Preparing Stock Solutions for SLV 320

The following data is based on the product molecular weight 308.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.24 mL 16.21 mL 32.43 mL
5 mM 0.65 mL 3.24 mL 6.49 mL
10 mM 0.32 mL 1.62 mL 3.24 mL
50 mM 0.06 mL 0.32 mL 0.65 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 16 publications citing the usage of this product.

Product Documents for SLV 320

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SLV 320

For research use only

Customer Reviews for SLV 320 (1)

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  • SLV320 to inhibit adenosine A1 receptor in piglet afferent arteriole
    Name: Hitesh Soni
    Species: Pig
    Assay Type: In Vitro
    Cell Line/Tissue: Renal Afferent Arteriole
    Verified Customer | Posted 01/04/2018
    To inhibit adenosine A1 receptor in isolated pig afferent arteriole from kidney. We have performed calcium imaging study using this compound. We have also used pyr3 from Tocris and published results in AJP-renal journal recently. American Journal of Physiology-Renal Physiology 313 (6), F1216-F1222
    SLV 320 3344

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