Chemical Name: trans-4-[(2-Phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexanol
Biological ActivityPotent and selective adenosine A1 receptor antagonist (Ki values are 1, 200, 398 and 3981 nM at human A1, A3, A2A and A2B receptors respectively). Suppresses cardiac fibrosis and attenuates albuminuria, without effect on blood pressure in animal models of chronic renal failure. Orally active.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
The adenosine A1 receptor antagonist SLV320 reduces myocardial fibrosis in rats with 5/6 nephrectomy without effecting blood pressure.
Kalk et al.
Citations for SLV 320
The citations listed below are publications that use Tocris products. Selected citations for SLV 320 include:
2 Citations: Showing 1 - 2
Selective modulation of the androgen receptor AF2 domain rescues degeneration in spinal bulbarmuscular atrophy.
Nat Med 2018;24(4):424
Structures of Human A1 and A2A Adenosine Receptors with Xanthines Reveal Determinants of Selectivity.
Authors: Cheng Et al.
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To inhibit adenosine A1 receptor in isolated pig afferent arteriole from kidney. We have performed calcium imaging study using this compound. We have also used pyr3 from Tocris and published results in AJP-renal journal recently. American Journal of Physiology-Renal Physiology 313 (6), F1216-F1222