SLV 320

Catalog # Availability Size / Price Qty
3344/10
3344/50
SLV 320 | CAS No. 251945-92-3 | Adenosine A1 Receptor Antagonists
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Description: Potent and selective A1 antagonist

Chemical Name: trans-4-[(2-Phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexanol

Purity: ≥99%

Product Details
Citations (2)
Supplemental Products
Reviews (1)

Biological Activity

Potent and selective adenosine A1 receptor antagonist (Ki values are 1, 200, 398 and 3981 nM at human A1, A3, A2A and A2B receptors respectively). Suppresses cardiac fibrosis and attenuates albuminuria, without effect on blood pressure in animal models of chronic renal failure. Orally active.

Technical Data

M.Wt:
308.38
Formula:
C18H20N4O
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
251945-92-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for SLV 320

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SLV320 to inhibit adenosine A1 receptor in piglet afferent arteriole
By Hitesh Soni on 01/04/2018
Species: Other

To inhibit adenosine A1 receptor in isolated pig afferent arteriole from kidney. We have performed calcium imaging study using this compound. We have also used pyr3 from Tocris and published results in AJP-renal journal recently. American Journal of Physiology-Renal Physiology 313 (6), F1216-F1222

PMID: 28855189

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