Potent and selective adenosine A1
receptor antagonist (Ki
values are 1, 200, 398 and 3981 nM at human A1
receptors respectively). Suppresses cardiac fibrosis and attenuates albuminuria, without effect on blood pressure in animal models of chronic renal failure. Orally active.
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The adenosine A1 receptor antagonist SLV320 reduces myocardial fibrosis in rats with 5/6 nephrectomy without effecting blood pressure.
Kalk et al.