Chemical Name: (±)-Tropanyl 2-(4-chlorophenoxy)butanoate maleate
Biological ActivitySM-21 maleate is a potent and selective σ2 antagonist with central effects following systemic administration. Causes increased release of acetylcholine at central muscarinic synapses. Potent analgesic (efficacy comparable to morphine) and nootropic agent.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Antinociceptive profile of 3-α-tropanyl-(2-Cl)-acid phenoxybutyrate (SM-21): a novel analgesic with a presynaptic cholinergic mechanism of action.
Ghelardini et al.
Pharmacological identification of SM-21, the novel σ2 antagonist.
Ghelardini et al.
(±)-SM 21 attenuates the convulsive and locomotor stimulatory effects of cocaine in mice.
Matsumoto and Mack
Citations for SM-21 maleate
The citations listed below are publications that use Tocris products. Selected citations for SM-21 maleate include:
3 Citations: Showing 1 - 3
Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells.
Authors: Dolma Et al.
Cancer Cell 2016;29:859
Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by ifenprodil: the role of σ-1 and IP3 receptors.
Authors: Ishima and Hashimoto
J Diabetes Res 2012;7:e37989
Effects of UMB24 and (+/-)-SM 21, putative σ2-preferring antagonists, on behavioral toxic and stimulant effects of cocaine in mice.
Authors: Matsumoto Et al.
PLoS One 2007;86:86
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