SM-21 maleate

Key Product Details

Product Description

SM-21 maleate is a potent and selective σ₂ antagonist with central effects following systemic administration. Causes increased release of acetylcholine at central muscarinic synapses. Potent analgesic (efficacy comparable to morphine) and nootropic agent.

Product Specifications for SM-21 maleate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SM-21 maleate

The following data is based on the product molecular weight 453.92.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	8.81 mL	44.06 mL	88.12 mL
1.25 mM	1.76 mL	8.81 mL	17.62 mL
2.5 mM	0.88 mL	4.41 mL	8.81 mL
12.5 mM	0.18 mL	0.88 mL	1.76 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 13 publications citing the usage of this product.

• Ghelardini Pharmacological identification of SM-21, the novel σ₂ antagonist. Pharmacol.Biochem.Behav. 2000 PMID: 11164098
• Matsumoto and Mack (±)-SM 21 attenuates the convulsive and locomotor stimulatory effects of cocaine in mice. Eur.J.Pharmacol. 2001 PMID: 11301071
• Ghelardini Antinociceptive profile of 3-α-tropanyl-(2-Cl)-acid phenoxybutyrate (SM-21): a novel analgesic with a presynaptic cholinergic mechanism of action. J.Pharmacol.Exp.Ther. 1997 PMID: 9223584

Product Documents for SM-21 maleate