Chemical Name: (±)-Tropanyl 2-(4-chlorophenoxy)butanoate maleate
Biological ActivityPotent and selective σ2 antagonist with central effects following systemic administration. Causes increased release of acetylcholine at central muscarinic synapses. Potent analgesic (efficacy comparable to morphine) and nootropic agent.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Antinociceptive profile of 3-α-tropanyl-(2-Cl)-acid phenoxybutyrate (SM-21): a novel analgesic with a presynaptic cholinergic mechanism of action.
Ghelardini et al.
Pharmacological identification of SM-21, the novel σ2 antagonist.
Ghelardini et al.
(±)-SM 21 attenuates the convulsive and locomotor stimulatory effects of cocaine in mice.
Matsumoto and Mack
Citations for SM-21 maleate
The citations listed below are publications that use Tocris products. Selected citations for SM-21 maleate include:
3 Citations: Showing 1 - 3
Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells.
Authors: Dolma Et al.
Cancer Cell 2016;29:859
Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by ifenprodil: the role of σ-1 and IP3 receptors.
Authors: Ishima and Hashimoto
J Diabetes Res 2012;7:e37989
Effects of UMB24 and (+/-)-SM 21, putative σ2-preferring antagonists, on behavioral toxic and stimulant effects of cocaine in mice.
Authors: Matsumoto Et al.
PLoS One 2007;86:86
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