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SMANT hydrochloride

4662 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4662/10
4662/50
Other Smoothened Receptor Compounds Small Molecule
1 Image
Description: Inhibits Smoothened (Smo) accumulation

Chemical Name: N-(4-Bromophenyl)-3,5-dimethyl-1-piperidinepropanamide hydrochloride

Purity: ≥99%

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Biological Activity

Inhibitor of Smoothened (Smo) signaling via a unique mechanism. Inhibits Shh-induced accumulation of Smo::EGFP fusion protein in the primary cilium (IC50 = 1.1 μM). Inhibits both wild-type Smo and an oncogenic form (SmoM2) with similar efficacy.

Technical Data

M.Wt:
375.73
Formula:
C16H23BrN2O.HCl
Solubility:
Soluble to 20 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
1177600-74-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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VersaClone cDNA Plasmids

Human Smoothened (NP_005622) VersaClone cDNA

RDC2144

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