Chemical Name: N-(4-Bromophenyl)-3,5-dimethyl-1-piperidinepropanamide hydrochloride
Biological ActivitySMANT hydrochloride is an inhibitor of Smoothened (Smo) signaling via a unique mechanism. Inhibits Shh-induced accumulation of Smo::EGFP fusion protein in the primary cilium (IC50 = 1.1 μM). Inhibits both wild-type Smo and an oncogenic form (SmoM2) with similar efficacy.
The technical data provided above is for guidance only.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Selective identification of Hedgehog pathway antagonists by direct analysis of Smoothened ciliary translocation.
Wang et al.
ACS Chem.Biol., 2012;7:1040
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