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SMANT hydrochloride

4662 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4662/10
4662/50
Cat.No. 4662 - SMANT hydrochloride | C16H23BrN2O.HCl | CAS No. 1177600-74-6
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Description: Inhibits Smoothened (Smo) accumulation

Chemical Name: N-(4-Bromophenyl)-3,5-dimethyl-1-piperidinepropanamide hydrochloride

Purity: ≥99%

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Biological Activity

Inhibitor of Smoothened (Smo) signaling via a unique mechanism. Inhibits Shh-induced accumulation of Smo::EGFP fusion protein in the primary cilium (IC50 = 1.1 μM). Inhibits both wild-type Smo and an oncogenic form (SmoM2) with similar efficacy.

Technical Data

M.Wt:
375.73
Formula:
C16H23BrN2O.HCl
Solubility:
Soluble to 20 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
1177600-74-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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VersaClone cDNA Plasmids

Human Smoothened (NP_005622) VersaClone cDNA

RDC2144

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