Inhibitor of Smoothened (Smo) signaling via a unique mechanism. Inhibits Shh-induced accumulation of Smo::EGFP fusion protein in the primary cilium (IC50
= 1.1 μ
M). Inhibits both wild-type Smo and an oncogenic form (SmoM2) with similar efficacy.
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All Tocris products are intended for laboratory research use only.
Selective identification of Hedgehog pathway antagonists by direct analysis of Smoothened ciliary translocation.
Wang et al.
ACS Chem.Biol., 2012;7:1040