SMANT hydrochloride
Chemical Name: N-(4-Bromophenyl)-3,5-dimethyl-1-piperidinepropanamide hydrochloride
Purity: ≥99%
Biological Activity
Inhibitor of Smoothened (Smo) signaling via a unique mechanism. Inhibits Shh-induced accumulation of Smo::EGFP fusion protein in the primary cilium (IC50 = 1.1 μM). Inhibits both wild-type Smo and an oncogenic form (SmoM2) with similar efficacy.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Selective identification of Hedgehog pathway antagonists by direct analysis of Smoothened ciliary translocation.
Wang et al.
ACS Chem.Biol., 2012;7:1040
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