Catalog Number: 4662
Chemical Name: N-(4-Bromophenyl)-3,5-dimethyl-1-piperidinepropanamide hydrochloride
Biological Activity
Inhibitor of Smoothened (Smo) signaling via a unique mechanism. Inhibits Shh-induced accumulation of Smo::EGFP fusion protein in the primary cilium (IC50 = 1.1 μM). Inhibits both wild-type Smo and an oncogenic form (SmoM2) with similar efficacy.
Technical Data
  • M.Wt:
    375.73
  • Formula:
    C16H23BrN2O.HCl
  • Solubility:
    Soluble to 20 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    1177600-74-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Selective identification of Hedgehog pathway antagonists by direct analysis of Smoothened ciliary translocation.
    Wang et al.
    ACS Chem.Biol., 2012;7:1040

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