Chemical Name: N-(4-Bromophenyl)-3,5-dimethyl-1-piperidinepropanamide hydrochloride
Biological Activity Inhibitor of Smoothened (Smo) signaling via a unique mechanism. Inhibits Shh-induced accumulation of Smo::EGFP fusion protein in the primary cilium (IC50 = 1.1 μM). Inhibits both wild-type Smo and an oncogenic form (SmoM2) with similar efficacy.
Soluble to 20 mM in water and to 100 mM in DMSO
Desiccate at RT
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