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SMANT hydrochloride

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SMANT hydrochloride | CAS No. 1177600-74-6 | Other Smoothened Receptor Compounds
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Description: Inhibits Smoothened (Smo) accumulation

Chemical Name: N-(4-Bromophenyl)-3,5-dimethyl-1-piperidinepropanamide hydrochloride

Purity: ≥99%

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Biological Activity

SMANT hydrochloride is an inhibitor of Smoothened (Smo) signaling via a unique mechanism. Inhibits Shh-induced accumulation of Smo::EGFP fusion protein in the primary cilium (IC50 = 1.1 μM). Inhibits both wild-type Smo and an oncogenic form (SmoM2) with similar efficacy.

Technical Data

M.Wt:
375.73
Formula:
C16H23BrN2O.HCl
Solubility:
Soluble to 20 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
1177600-74-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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