Chemical Name: (S)-Nitroso-N-acetylpenicillamine
Biological ActivitySNAP is a stable analog of endogenous S-nitroso compounds. A source of NO in vivo which unlike organic O-nitrates does not induce tolerance. Decomposes slowly in solution with a t½ of 37h.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Neurotoxicity in conscious rats following intraventricular SNAP, a nitric oxide donor.
Cross et al.
Comparative effects of several nitric oxide donors on intracellular cyclic GMP levels in bovine chromaffin cells: correlation with nitric oxide production.
Ferrero et al.
Motor responses in rat ileum evoked by nitric oxide donors vs. field stimulation: modulation by pituitary adenylate cyclase-activating peptide, forskolin and guanylate cyclase inhibitors.
Ekblad and Sundler
Differential thermodynamic effects and tolerance properties of nitrogly. and S-nitrosothiol in experimental heart failure.
Bauer and Fung
Citations for SNAP
The citations listed below are publications that use Tocris products. Selected citations for SNAP include:
10 Citations: Showing 1 - 10
Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapsesfollowing acute stress
Endothelin-1 contributes to endothelial dysfunction and enhanced vasoconstriction through augmented superoxide production in penile arteries from Ins-resistant obese rats: role of ET(A) and ET(B) receptors.
Authors: Sánchez Et al.
Br J Pharmacol 2014;171:5682
Biphasic effect of nitric oxide on the cardiac voltage-dependent anion channel.
Authors: Cheng Et al.
FEBS Lett 2011;585:328
NO-released zinc supports the simultaneous binding of Raf-1 and PKCγ cysteine-rich domains to HINT1 protein at the mu-opioid receptor.
Authors: Rodríguez-Muñoz Et al.
Antioxid Redox Signal 2011;14:2413
Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of Ins-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-i
Authors: Sunters Et al.
J Biol Chem 2010;285:8743
Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex.
Authors: Huang and Hsu
Cereb Cortex 2010;20:982
Modulation of inhibitory activity by nitric oxide in the thalamus.
J Neurophysiol 2007;97:3386
Peripheral analgesic blockade of hypernociception: activation of arginine/NO/cGMP/protein kinase G/ATP-sensitive K+ channel pathway.
Authors: Sachs Et al.
Proc Natl Acad Sci U S A 2004;101:3680
High-Yield Method for Isolation and Culture of Endothelial Cells from Rat Coronary Blood Vessels Suitable for Analysis of Intracellular Calcium and Nitric Oxide Biosynthetic Pathways.
Authors: Nistri Et al.
Evid Based Complement Alternat Med 2002;4:32
In vivo microdialysis study of a specific inhibitor of soluble guanylyl cyclase on the glutamate receptor/nitric oxide/cyclic GMP pathway.
Authors: Fedele Et al.
Br J Pharmacol 1996;119:590
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