Catalog Number: 0598
Chemical Name: (S)-Nitroso-N-acetylpenicillamine
Biological Activity
A stable analog of endogenous S-nitroso compounds. A source of NO in vivo which unlike organic O-nitrates does not induce tolerance. Decomposes slowly in solution with a t½ of 37h.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Differential thermodynamic effects and tolerance properties of nitroglycerin and S-nitrosothiol in experimental heart failure.
    Bauer and Fung
    J.Pharmacol.Exp.Ther., 1991;256:249
  2. Comparative effects of several nitric oxide donors on intracellular cyclic GMP levels in bovine chromaffin cells: correlation with nitric oxide production.
    Ferrero et al.
    Br.J.Pharmacol., 1999;127:779
  3. Motor responses in rat ileum evoked by nitric oxide donors vs. field stimulation: modulation by pituitary adenylate cyclase-activating peptide, forskolin and guanylate cyclase inhibitors.
    Ekblad and Sundler
    J.Pharmacol.Exp.Ther., 1997;283:23
  4. Neurotoxicity in conscious rats following intraventricular SNAP, a nitric oxide donor.
    Cross et al.
    Neuropharmacology, 1994;33:915

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