Catalog Number: 1529
Chemical Name: 4-[(S)-[(2S,5R)-2,5-Dimethyl-4-(2-propenyl)-1-piperazinyl]phenylmethyl]-N,N-diethylbenzamide
Biological Activity
Potent and selective non-peptide δ-opioid receptor agonist (Ki = 0.63 nM). Displays > 8000-fold selectivity over μ-opioid receptors and is centrally active following systemic administration in vivo.
Technical Data
  • M.Wt:
    419.61
  • Formula:
    C27H37N3O
  • Solubility:
    Soluble to 100 mM in 1eq. HCl
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    178803-51-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Probes for narcotic receptor mediated phenomena. 23. Synthesis, opioid receptor binding, and bioassay of the highly selective δ agonist (+)-4-[(αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-<
    Calderon et al.
    J.Med.Chem., 1997;40:695
  2. Structure-activity relationships for SNC80 and related compounds at cloned human delta and mu opioid receptors.
    Knapp et al.
    J.Pharmacol.Exp.Ther., 1996;277:1284
  3. Behavioral effects of the delta-selective opioid agonist SNC80 and related compounds in rhesus monkeys.
    Negus et al.
    J.Pharmacol.Exp.Ther., 1998;286:362
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SNC 162 include:

2 Citations: Showing 1 - 2
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  1. A Broad G Protein-Coupled Receptor Internalization Assay that Combines SNAP-Tag Labeling, Diffusion-Enhanced Resonance Energy Transfer, and a Highly Emissive Terbium Cryptate.
    Authors: Levoye Et al.
    Cell Cycle 2015;6:167
  2. CXCR2 chemokine receptor antagonism enhances DOP opioid receptor function via allosteric regulation of the CXCR2-DOP receptor heterodimer.
    Authors: Parenty Et al.
    Biochem J 2008;412:245

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