Chemical Name: 4-[(S)-[(2S,5R)-2,5-Dimethyl-4-(2-propenyl)-1-piperazinyl]phenylmethyl]-N,N-diethylbenzamide
Biological ActivityPotent and selective non-peptide δ-opioid receptor agonist (Ki = 0.63 nM). Displays > 8000-fold selectivity over μ-opioid receptors and is centrally active following systemic administration in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Structure-activity relationships for SNC80 and related compounds at cloned human delta and mu opioid receptors.
Knapp et al.
Behavioral effects of the delta-selective opioid agonist SNC80 and related compounds in rhesus monkeys.
Negus et al.
Probes for narcotic receptor mediated phenomena. 23. Synthesis, opioid receptor binding, and bioassay of the highly selective δ agonist (+)-4-[(αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-<
Calderon et al.
Citations for SNC 162
The citations listed below are publications that use Tocris products. Selected citations for SNC 162 include:
2 Citations: Showing 1 - 2
A Broad G Protein-Coupled Receptor Internalization Assay that Combines SNAP-Tag Labeling, Diffusion-Enhanced Resonance Energy Transfer, and a Highly Emissive Terbium Cryptate.
Authors: Levoye Et al.
Cell Cycle 2015;6:167
CXCR2 chemokine receptor antagonism enhances DOP opioid receptor function via allosteric regulation of the CXCR2-DOP receptor heterodimer.
Authors: Parenty Et al.
Biochem J 2008;412:245
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