Chemical Name: 4-[(S)-[(2S,5R)-2,5-Dimethyl-4-(2-propenyl)-1-piperazinyl]phenylmethyl]-N,N-diethylbenzamide
Biological ActivityPotent and selective non-peptide δ-opioid receptor agonist (Ki = 0.63 nM). Displays > 8000-fold selectivity over μ-opioid receptors and is centrally active following systemic administration in vivo.
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Probes for narcotic receptor mediated phenomena. 23. Synthesis, opioid receptor binding, and bioassay of the highly selective δ agonist (+)-4-[(αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-<
Calderon et al.
Structure-activity relationships for SNC80 and related compounds at cloned human delta and mu opioid receptors.
Knapp et al.
Behavioral effects of the delta-selective opioid agonist SNC80 and related compounds in rhesus monkeys.
Negus et al.
Citations for SNC 162
The citations listed below are publications that use Tocris products. Selected citations for SNC 162 include:
2 Citations: Showing 1 - 2
A Broad G Protein-Coupled Receptor Internalization Assay that Combines SNAP-Tag Labeling, Diffusion-Enhanced Resonance Energy Transfer, and a Highly Emissive Terbium Cryptate.
Authors: Levoye Et al.
Cell Cycle 2015;6:167
CXCR2 chemokine receptor antagonism enhances DOP opioid receptor function via allosteric regulation of the CXCR2-DOP receptor heterodimer.
Authors: Parenty Et al.
Biochem J 2008;412:245
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