Histone deacetylase inhibitor that displays anticancer activity. Inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. Also inhibits protein isoprenylation, depletes plasma glutamine, increases production of fetal hemoglobin through transcriptional activation of the γ
-globin gene and affects hPPARγ
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Histone deacetylase inhibitor 4-phenylbutyrate suppresses GADPH mRNA expression in glioma cells.
Appelskog et al.
Complementary effects of HDAC inhibitor 4-PB on gap junction communication and cellular export mechanisms support restoration of chemosensitivity of PDAC cells.
Ammerpohl et al.
HDAC inhibitor 4-phenylbutyrate preserves immature phenotype of human embryonic midbrain stem cells: implications for the involvement of DNA methyltransferase.
Khan et al.
Inhibitory effects of phenylbutyrate on the proliferation, morphology, migration and invasiveness of malignant glioma cells.
Engelhard et al.
The citations listed below are publications that use Tocris products. Selected citations for Sodium 4-Phenylbutyrate include:
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