Catalog Number: 3850
Chemical Name: Butanoic acid sodium salt
Biological Activity
Histone deacetylase inhibitor. Restores contextual memory in a transgenic mouse model of Alzheimer's disease. Shown to induce pancreatic progenitor formation. Directs the differentiation of mouse embryonic stem cells into hepatocytes when used in combination with the cytokine Activin A. Also augments transcription factor stimulated iPSC generation.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Suppression of histone deacetylation in vivo and in vitro by sodium butyrate.
    Boffa et al.
    J.Biol.Chem., 1978;253:3364
  2. Inhibitors of class 1 histone deacetylases reverse contextual deficits in a mouse model of Alzheimer's disease.
    Kilgore et al.
    Neuropsychopharmacology, 2010;35:870
  3. Effects of sodium butyrate on the differentiation of pancreatic and hepatic progenitor cells from mouse embryonic stem cells.
    Ren et al.
    J.Cell Biochem., 2010;109:236
  4. Differentiation of mouse embryonic stem cells into hepatocytes induced by a combination of cytokines and sodium butyrate.
    Zhou et al.
    J.Cell Biochem., 2010;109:606
  5. Butyrate promotes induced pluripotent stem cell generation.
    Liang et al.
    J.Biol.Chem., 2010;285:25516
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