Chemical Name: Butanoic acid sodium salt
Biological ActivityHistone deacetylase inhibitor. Restores contextual memory in a transgenic mouse model of Alzheimer's disease. Shown to induce pancreatic progenitor formation. Directs the differentiation of mouse embryonic stem cells into hepatocytes when used in combination with the cytokine Activin A. Also augments transcription factor stimulated iPSC generation.
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Butyrate promotes induced pluripotent stem cell generation.
Liang et al.
Suppression of histone deacetylation in vivo and in vitro by sodium butyrate.
Boffa et al.
Inhibitors of class 1 histone deacetylases reverse contextual deficits in a mouse model of Alzheimer's disease.
Kilgore et al.
Effects of sodium butyrate on the differentiation of pancreatic and hepatic progenitor cells from mouse embryonic stem cells.
Ren et al.
J.Cell Biochem., 2010;109:236
Differentiation of mouse embryonic stem cells into hepatocytes induced by a combination of cytokines and sodium butyrate.
Zhou et al.
J.Cell Biochem., 2010;109:606
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