Spantide I

Name: Spantide I
Brand: Tocris Bioscience
SKU: 1784

Tocris Bioscience | Catalog # 1784

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Product Documents

Selective NK1 antagonist

Discontinued Product

1784 has been discontinued. View all NK1 Receptor Antagonists products.

Technical Data
Reviews

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Selective NK1 antagonist

Alternative Names

[D-Arg¹,D-Trp^7,9,Leu¹¹]-Substance P

View all NK1 Receptor Antagonists »

Product Description

Spantide I is a selective NK₁ receptor antagonist (K_i values are 230, 8150 and > 10000 nM for rat NK₁, NK₂ and NK₃ receptors respectively). Active in vivo.

Product Specifications for Spantide I

Molecular Weight

1497.80

Formula

C₇₅H₁₀₈N₂₀O₁₃

Storage

Desiccate at -20°C

CAS Number

91224-37-2

PubChem ID

25079075

InChI Key

SAPCBHPQLCZCDV-CHPWDEGWSA-N

SMILES

[H]N[C@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product.

Folkers Biological evaluation of substance P antagonists. Br.J.Pharmacol. 1984 PMID: 6207886
Zubrzycka Comparison of antagonistic properties of substance P analogs, spantide I, II and III, on evoked tongue jerks in rats. Endocr.Regul. 2000 PMID: 10808247
Beaujouan Higher potency of RP 67580, in the mouse and the rat compared with other nonpeptide and peptide tachykinin NK₁ antagonists. Br.J.Pharmacol. 1993 PMID: 7682138

Product Documents for Spantide I

Certificate of Analysis

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Product Specific Notices for Spantide I

For research use only

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