Spantide I
1 Image
Description: Selective NK1 antagonist
Alternative Names: [D-Arg1,D-Trp7,9,Leu11]-Substance P
Biological Activity
Selective NK1 receptor antagonist (Ki values are 230, 8150 and > 10000 nM for rat NK1, NK2 and NK3 receptors respectively). Active in vivo.Technical Data
M.Wt:
1497.8
Formula:
C75H108N20O13
Sequence:
RPKPQQWFWLL
(Modifications: Arg-1 = D-Arg, Trp-7 = Trp-9 = D-Trp)
Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
91224-37-2
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Higher potency of RP 67580, in the mouse and the rat compared with other nonpeptide and peptide tachykinin NK1 antagonists.
Beaujouan et al.
Br.J.Pharmacol., 1993;108:793 -
Biological evaluation of substance P antagonists.
Folkers et al.
Br.J.Pharmacol., 1984;83:449 -
Comparison of antagonistic properties of substance P analogs, spantide I, II and III, on evoked tongue jerks in rats.
Zubrzycka et al.
Endocr.Regul., 2000;34:13
Product Datasheets
or select another batch:
Reconstitution Calculator
Molarity Calculator
Reconstitution Calculator
Molarity Calculator
FAQs
No product specific FAQs exist for this product, however you may
View all Peptide FAQsVersaClone cDNA Plasmids
Reviews for Spantide I
There are currently no reviews for this product. Be the first to review Spantide I and earn rewards!
Have you used Spantide I?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Tocris Bioscience is the leading supplier of novel and exclusive
tools for
life science research with over 30 years' experience in the
industry.
Tocris is a Bio-Techne brand.
