Spantide I
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Description: Selective NK1 antagonist
Alternative Names: [D-Arg1,D-Trp7,9,Leu11]-Substance P
Biological Activity
Spantide I is a selective NK1 receptor antagonist (Ki values are 230, 8150 and > 10000 nM for rat NK1, NK2 and NK3 receptors respectively). Active in vivo.Technical Data
M.Wt:
1497.8
Formula:
C75H108N20O13
Sequence:
RPKPQQWFWLL
(Modifications: Arg-1 = D-Arg, Trp-7 = Trp-9 = D-Trp)
Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
91224-37-2
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Background References
-
Higher potency of RP 67580, in the mouse and the rat compared with other nonpeptide and peptide tachykinin NK1 antagonists.
Beaujouan et al.
Br.J.Pharmacol., 1993;108:793 -
Biological evaluation of substance P antagonists.
Folkers et al.
Br.J.Pharmacol., 1984;83:449 -
Comparison of antagonistic properties of substance P analogs, spantide I, II and III, on evoked tongue jerks in rats.
Zubrzycka et al.
Endocr.Regul., 2000;34:13
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FAQs
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