Inhibitor of autophagy; inhibits USP10 and USP13 activity (IC50
values are 0.6 and 0.7 μ
M respectively) and promotes degradation of Vps34 (class III PI 3-kinase) complexes. Selectively promotes apoptosis of cancer cells under starvation conditions. Prevents the PDGF-induced conversion from the contractile to synthetic phenotype in vascular smooth muscle cells.
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PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and resistance to oxidative stress.
Salabei et al.
Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13.
Liu et al.