Catalog Number: 5197
Chemical Name: 6-Fluoro-N-[(4-Fluorophenyl)methyl]-4-quinazolinamine
Biological Activity
Inhibitor of autophagy; inhibits USP10 and USP13 activity (IC50 values are 0.6 and 0.7 μM respectively) and promotes degradation of Vps34 (class III PI 3-kinase) complexes. Selectively promotes apoptosis of cancer cells under starvation conditions. Prevents the PDGF-induced conversion from the contractile to synthetic phenotype in vascular smooth muscle cells.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and resistance to oxidative stress.
    Salabei et al.
    Biochem.J., 2013;451:375
  2. Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13.
    Liu et al.
    Cell, 2011;147:223
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