Spautin 1

Key Product Details

Product Description

Spautin 1 is an inhibitor of autophagy; inhibits USP10 and USP13 activity (IC₅₀ values are 0.6 and 0.7 μM respectively) and promotes degradation of Vps34 (class III PI 3-kinase) complexes. Selectively promotes apoptosis of cancer cells under starvation conditions. Prevents the PDGF-induced conversion from the contractile to synthetic phenotype in vascular smooth muscle cells.

Product Specifications for Spautin 1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Spautin 1

The following data is based on the product molecular weight 271.26.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.69 mL	18.43 mL	36.87 mL
5 mM	0.74 mL	3.69 mL	7.37 mL
10 mM	0.37 mL	1.84 mL	3.69 mL
50 mM	0.07 mL	0.37 mL	0.74 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

• Liu Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell 2011 PMID: 21962518
• Salabei PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and resistance to oxidative stress. Biochem.J. 2013 PMID: 23421427

Product Documents for Spautin 1