Biological ActivitySpexin is a potent galanin receptor 2/3 (GAL2/GAL3) agonist (EC50 values are 45.7 and 112.2 nM, respectively). Exhibits no significant activity at galanin receptor 1. Endogenous satiety-inducing peptide; inhibits long chain fatty acid uptake by adipocytes and decreases food consumption in diet-induced obese mice and rats. Attenuates LH secretion in goldfish. Exhibits anxiolytic effects in vivo.
(Modifications: Gln-14 = C-terminal amide)
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Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet-induced obesity
Walewski et al.
Obesity (Silver Spring), 2014;22:1643
Development of spexin-based human galanin receptor type II-specific agonists with increased stability in serum and anxiolytic effect in mice.
Reyes-Alcaraz et al.
Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III.
Kim et al.
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