Catalog Number: 1435
Chemical Name: 9-(Tetrahydro-2-furanyl)-9H-purin-6-amine
Biological Activity
Inhibitor of adenylyl cyclase (IC50 = 1.4 μM). Inhibits PGE1-stimulated increases in cAMP levels in intact human platelets.
Technical Data
  • M.Wt:
    205.22
  • Formula:
    C9H11N5O
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    17318-31-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Role of cyclic nucleotides in vasodilations of the rat thoracic aorta induced by adenosine analogues.
    Hourani et al.
    Br.J.Pharmacol., 2001;133:833
  2. Inhibition of adenylate cyclase of catfish and rat hepatocyte membranes by 9-(tetrahydro-2-furyl)adenine (SQ 22536).
    Fabbri et al.
    J.Enzyme Inhib., 1991;5:87
  3. Inhibition of adenylate cyclase in human blood platelets by 9-substituted adenine derivatives.
    Harris et al.
    J.Cyclic Nucleotide Res., 1979;5:125
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SQ 22536 include:

8 Citations: Showing 1 - 8
Filter your results:

  1. β2-adrenoreceptor Inverse Agonist Down-regulates Muscarine Cholinergic Subtype-3 Receptor and Its Downstream Signal Pathways in Airway Smooth Muscle Cells in vitro.
    Authors: Luo
    Scientific Reports 2017;7:39905
  2. The Vasopressin Type-2 Receptor and Prostaglandin Receptors EP2 and EP4 can Increase Aquaporin-2 Plasma Membrane Targeting Through a cAMP Independent Pathway.
    Authors: Olesen Et al.
    American Journal of Physiology - Renal Physiology 2016;
  3. Lactate-mediated glia-neuronal signalling in the mammalian brain.
    Authors: Tang Et al.
    Nat Commun 2014;5:3284
  4. cAMP level modulates scleral collagen remodeling, a critical step in the development of myopia.
    Authors: Tao Et al.
    Biochim Biophys Acta 2013;8:e71441
  5. Genistein prevents hyperglycemia-induced monocyte adhesion to human aortic endothelial cells through preservation of the cAMP signaling pathway and ameliorates vascular inflammation in obese diabetic mice.
    Authors: Babu Et al.
    J Nutr 2012;142:724
  6. β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons.
    Authors: Meitzen Et al.
    J Neurochem 2011;116:984
  7. C5a mediates peripheral blood neutrophil dysfunction in critically ill patients.
    Authors: Morris Et al.
    Am J Respir Crit Care Med 2009;180:19
  8. Inhibition of erythroblast growth and fetal hemoglobin production by ribofuranose-substituted adenosine derivatives.
    Authors: Bhanu Et al.
    PLoS One 2008;1782:504

Have you used SQ 22536?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 

Feedback

Customer Information