SQ 22536

  ( 9 citations )    
Product Datasheet
Catalog Number:1435
Chemical Name:9-(Tetrahydro-2-furanyl)-9H-purin-6-amine
Product Details
Citations (9)
Reviews
Biological Activity
Inhibitor of adenylyl cyclase (IC50 = 1.4 μM). Inhibits PGE1-stimulated increases in cAMP levels in intact human platelets. Cell permeable.
Technical Data
  • M.Wt:
    205.22
  • Formula:
    C9H11N5O
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >99
  • Storage:
    Desiccate at +4°C
  • CAS No:
    17318-31-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for SQ 22536 include:

9 Citations: Showing 1 - 9
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  1. β2-adrenoreceptor Inverse Agonist Down-regulates Muscarine Cholinergic Subtype-3 Receptor and Its Downstream Signal Pathways in Airway Smooth Muscle Cells in vitro.
    Authors: Luo
    Scientific Reports  2017;7:39905
  2. The Vasopressin Type-2 Receptor and Prostaglandin Receptors EP2 and EP4 can Increase Aquaporin-2 Plasma Membrane Targeting Through a cAMP Independent Pathway.
    Authors: Olesen Et al.
    American Journal of Physiology - Renal Physiology  2016;
  3. Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability.
    Authors: Du Et al.
    FASEB J  2015;29:2194
  4. Lactate-mediated glia-neuronal signalling in the mammalian brain.
    Authors: Tang Et al.
    Nat Commun  2014;5:3284
  5. cAMP level modulates scleral collagen remodeling, a critical step in the development of myopia.
    Authors: Tao Et al.
    Biochim Biophys Acta  2013;8:e71441
  6. Genistein prevents hyperglycemia-induced monocyte adhesion to human aortic endothelial cells through preservation of the cAMP signaling pathway and ameliorates vascular inflammation in obese diabetic mice.
    Authors: Babu Et al.
    J Nutr  2012;142:724
  7. β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons.
    Authors: Meitzen Et al.
    J Neurochem  2011;116:984
  8. C5a mediates peripheral blood neutrophil dysfunction in critically ill patients.
    Authors: Morris Et al.
    Am J Respir Crit Care Med  2009;180:19
  9. Inhibition of erythroblast growth and fetal hemoglobin production by ribofuranose-substituted adenosine derivatives.
    Authors: Bhanu Et al.
    PLoS One  2008;1782:504

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