Squarunkin A hydrochloride

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Squarunkin A hydrochloride | CAS No. 2253744-55-5 | Src Family Kinase Inhibitors
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Description: UNC119 chaperone-cargo interaction inhibitor; disrupts Src activation

Chemical Name: Ethyl 4-((3,4-dioxo-2-((2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)amino)cyclobut-1-en-1-yl)amino)piperidine-1-carboxylate hydrochloride

Purity: ≥98%

Product Details

Biological Activity

Squarunkin A hydrochloride is a potent inhibitor of UNC119 chaperone protein-cargo interaction (IC50 = 10 nM for inhibition of UNC119A - myristoylated Src N-terminal peptide interaction). Disrupts activation of Src kinase in vitro.

Technical Data

Soluble to 50 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Small-molecule inhibition of the UNC119-cargo interaction.
    Mejuch et al.
    Angew.Chem.Int.Ed., 2017;56:6181

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