Squarunkin A hydrochloride

Catalog # Availability Size / Price Qty
6364/50
6364/10
Cat.No. 6364 - Squarunkin A hydrochloride | C25H32F3N5O4.HCl
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Description: UNC119 chaperone-cargo interaction inhibitor; disrupts Src activation

Chemical Name: Ethyl 4-((3,4-dioxo-2-((2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)amino)cyclobut-1-en-1-yl)amino)piperidine-1-carboxylate hydrochloride

Purity: ≥98%

Product Details
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Biological Activity

Potent inhibitor of UNC119 chaperone protein-cargo interaction (IC50 = 10 nM for inhibition of UNC119A - myristoylated Src N-terminal peptide interaction). Disrupts activation of Src kinase in vitro.

Technical Data

M.Wt:
560.01
Formula:
C25H32F3N5O4.HCl
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Small-molecule inhibition of the UNC119-cargo interaction.
    Mejuch et al.
    Angew.Chem.Int.Ed., 2017;56:6181

Product Datasheets

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