Catalog Number: 3411
Alternate Names: BMS 649
Chemical Name: 4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dioxolan-2-yl]-benzoic acid
Biological Activity
Pan retinoid X receptor (RXR) agonist that is devoid of any RAR activity.
Technical Data
  • M.Wt:
    380.48
  • Formula:
    C24H28O4
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    146670-40-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Distinct retinoid X receptor-retinoic acid receptor heterodimers are differentially involved in the control of expression of retinoid target genes in F9 embryonal carcinoma cells.
    Chiba et al.
    Mol.Cell.Biol., 1997;17:3013
  2. RAR-independent RXR signaling induces t(15;17) leukemia cell maturation.
    Benoit et al.
    EMBO J., 1999;18:7011
  3. Retinoid X receptor agonists inhibit phorbol-12-myristate-13-acetate (PMA)-induced differentiation of monocytic THP-1 cells into macrophages.
    Zhou et al.
    Mol.Cell.Biochem., 2010;335:283

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