Chemical Name: 4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dioxolan-2-yl]-benzoic acid
Biological ActivitySR 11237 is a pan retinoid X receptor (RXR) agonist that is devoid of any RAR activity.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Distinct retinoid X receptor-retinoic acid receptor heterodimers are differentially involved in the control of expression of retinoid target genes in F9 embryonal carcinoma cells.
Chiba et al.
RAR-independent RXR signaling induces t(15;17) leukemia cell maturation.
Benoit et al.
EMBO J., 1999;18:7011
Retinoid X receptor agonists inhibit phorbol-12-myristate-13-acetate (PMA)-induced differentiation of monocytic THP-1 cells into macrophages.
Zhou et al.
Citation for SR 11237
The citations listed below are publications that use Tocris products. Selected citations for SR 11237 include:
1 Citation: Showing 1 - 1
Bladder-cancer-associated mutations in RXRA activate peroxisome proliferator-activated receptors to drive urothelial proliferation.
Authors: Halstead Et al.
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