Highly potent and selective JNK3 inhibitor (IC50
= 7 nM); exhibits > 2800-fold selectivity over p38.
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All Tocris products are intended for laboratory research use only.
Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-Jun N-terminal kinase 3 (JNK3) over p38.
Kamenecka et al.
J Biol Chem., 2009;284:12853