SR 59230A hydrochloride

Key Product Details

Product Description

SR 59230A hydrochloride is a potent and selective β₃ adrenoceptor antagonist (IC₅₀ values are 40, 408 and 648 nM for β₃, β₁ and β₂ receptors respectively). Orally active in vivo.

Product Specifications for SR 59230A hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SR 59230A hydrochloride

The following data is based on the product molecular weight 361.91.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.76 mL	13.82 mL	27.63 mL
5 mM	0.55 mL	2.76 mL	5.53 mL
10 mM	0.28 mL	1.38 mL	2.76 mL
50 mM	0.06 mL	0.28 mL	0.55 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 22 publications citing the usage of this product.

• Mizuno Stimulation of β₃-adrenoceptors causes phosphorylation of p38 mitogen-activated protein kinase via a stimulatory G protein-dependent pathway in 3T3-L1 adipocytes. Br.J.Pharmacol. 2002 PMID: 11861323
• Manara Aryloxypropanolaminotetralins are the first selective antagonists for atypical (β₃) β-adrenoceptors. Pharmacol.Comm.
• Manara Functional identification of rat atypical β-adrenoceptors by the first β₃-selective antagonists, aryloxypropanolaminotetralins. Br.J.Pharmacol. 1996 PMID: 8821531

Product Documents for SR 59230A hydrochloride