SR 59230A hydrochloride
Chemical Name: 1-(2-Ethylphenoxy)-3-[[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]-(2S)-2-propanol hydrochloride
Biological ActivityPotent and selective β3 adrenoceptor antagonist (IC50 values are 40, 408 and 648 nM for β3, β1 and β2 receptors respectively). Orally active in vivo. Also available as part of the β-Adrenoceptor Antagonist Tocriset™.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Olanzapine: preclinical and clinical profiles of a novel antipsychotic agent.
Tollefson and Taylor
CNS Drug Reviews, 2000;6:303
Stimulation of β3-adrenoceptors causes phosphorylation of p38 mitogen-activated protein kinase via a stimulatory G protein-dependent pathway in 3T3-L1 adipocytes.
Mizuno et al.
Functional identification of rat atypical β-adrenoceptors by the first β3-selective antagonists, aryloxypropanolaminotetralins.
Manara et al.
Aryloxypropanolaminotetralins are the first selective antagonists for atypical (β3) β-adrenoceptors.
Manara et al.
Citations for SR 59230A hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for SR 59230A hydrochloride include:
14 Citations: Showing 1 - 10
E2 Regulates Energy Balance by Ameliorating Hypothalamic Ceramide-Induced ER Stress.
Authors: González-García Et al.
Cell Rep 2018;25:413
β2-Adrenergic Receptor Antagonism Attenuates CNV Through Inhibition of VEGF and IL-6 Expression.
Invest Ophthalmol Vis Sci 2017;58(1):299
Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance.
Authors: Martínez-Sánchez Et al.
Cell Metab 2017;26:212
Adrenergic regulation of monocyte chemotactic protein 1 leads to enhanced macrophage recruitment and ovarian carcinoma growth.
Authors: Armaiz-Pena Et al.
Adrenergic DNA damage of embryonic pluripotent cells via β2 receptor signalling.
Authors: Sun Et al.
J Neuroimmunol 2015;5:15950
Bone marrow-derived microglia infiltrate into the paraventricular nucleus of chronic psychological stress-loaded mice.
Authors: Ataka Et al.
PLoS One 2013;8:e81744
NE potentiates proinflammatory responses of human vaginal epithelial cells.
Authors: Brosnahan Et al.
J Neurosci 2013;259:42583
Attenuation of choroidal neovascularization by β(2)-adrenoreceptor antagonism.
Authors: Lavine Et al.
JAMA Ophthalmol 2013;131:376
Modulation of calcium-dependent inactivation of L-type Ca2+ channels via β-adrenergic signaling in thalamocortical relay neurons.
Authors: Rankovic Et al.
PLoS One 2011;6:e27474
Leptin action in the dorsomedial hypothalamus increases sympathetic tone to brown adipose tissue in spite of systemic leptin resistance.
Authors: Enriori Et al.
Mamm Genome 2011;31:12189
Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis.
Authors: Sood Et al.
J Clin Invest 2010;120:1515
Ectopic activity in the rat pulmonary vein can arise from simultaneous activation of alpha1- and beta1-adrenoceptors.
Authors: Maupoil Et al.
Br J Pharmacol 2007;150:899
Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors.
Authors: Nackley Et al.
Involvement of β 3-adrenergic receptor activation via cyclic GMP- but not NO-dependent mechanisms in human corpus cavernosum function.
Authors: Cirino Et al.
Sci Rep 2003;100:5531
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