SR 59230A hydrochloride

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1511/10
1511/50
SR 59230A hydrochloride | CAS No. 1135278-41-9 | Adrenergic beta-3 Receptor Antagonists
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Description: Potent and selective β3 antagonist

Chemical Name: 1-(2-Ethylphenoxy)-3-[[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]-(2S)-2-propanol hydrochloride

Purity: ≥98%

Product Details
Citations (14)
Supplemental Products
Reviews

Biological Activity

Potent and selective β3 adrenoceptor antagonist (IC50 values are 40, 408 and 648 nM for β3, β1 and β2 receptors respectively). Orally active in vivo. Also available as part of the β-Adrenoceptor Antagonist Tocriset™.

Technical Data

M.Wt:
361.91
Formula:
C21H27NO2.HCl
Solubility:
Soluble to 10 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
1135278-41-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Olanzapine: preclinical and clinical profiles of a novel antipsychotic agent.
    Tollefson and Taylor
    CNS Drug Reviews, 2000;6:303
  2. Stimulation of β3-adrenoceptors causes phosphorylation of p38 mitogen-activated protein kinase via a stimulatory G protein-dependent pathway in 3T3-L1 adipocytes.
    Mizuno et al.
    Br.J.Pharmacol., 2002;135:951
  3. Functional identification of rat atypical β-adrenoceptors by the first β3-selective antagonists, aryloxypropanolaminotetralins.
    Manara et al.
    Br.J.Pharmacol., 1996;117:435
  4. Aryloxypropanolaminotetralins are the first selective antagonists for atypical (β3) β-adrenoceptors.
    Manara et al.
    Pharmacol.Comm., 1995;6:253

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Citations for SR 59230A hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for SR 59230A hydrochloride include:

14 Citations: Showing 1 - 10

  1. E2 Regulates Energy Balance by Ameliorating Hypothalamic Ceramide-Induced ER Stress.
    Authors: González-García Et al.
    Cell Rep  2018;25:413
  2. β2-Adrenergic Receptor Antagonism Attenuates CNV Through Inhibition of VEGF and IL-6 Expression.
    Authors: Lavine
    Invest Ophthalmol Vis Sci  2017;58(1):299
  3. Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance.
    Authors: Martínez-Sánchez Et al.
    Cell Metab  2017;26:212
  4. Adrenergic regulation of monocyte chemotactic protein 1 leads to enhanced macrophage recruitment and ovarian carcinoma growth.
    Authors: Armaiz-Pena Et al.
    Oncotarget  2015;6:4266
  5. Adrenergic DNA damage of embryonic pluripotent cells via β2 receptor signalling.
    Authors: Sun Et al.
    J Neuroimmunol  2015;5:15950
  6. Bone marrow-derived microglia infiltrate into the paraventricular nucleus of chronic psychological stress-loaded mice.
    Authors: Ataka Et al.
    PLoS One  2013;8:e81744
  7. NE potentiates proinflammatory responses of human vaginal epithelial cells.
    Authors: Brosnahan Et al.
    J Neurosci  2013;259:42583
  8. Attenuation of choroidal neovascularization by β(2)-adrenoreceptor antagonism.
    Authors: Lavine Et al.
    JAMA Ophthalmol  2013;131:376
  9. Modulation of calcium-dependent inactivation of L-type Ca2+ channels via β-adrenergic signaling in thalamocortical relay neurons.
    Authors: Rankovic Et al.
    PLoS One  2011;6:e27474
  10. Leptin action in the dorsomedial hypothalamus increases sympathetic tone to brown adipose tissue in spite of systemic leptin resistance.
    Authors: Enriori Et al.
    Mamm Genome  2011;31:12189

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