Potent and selective LIMK inhibitor (IC50
values are 43, 5536 and 6565 nM for LIMK1, ROCKI and ROCKII, respectively). Inhibits cofilin phosphorylation in A7r5 cells and suppresses migration and invasion of PC-3 cells in vitro
. Orally bioavailable.
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All Tocris products are intended for laboratory research use only.
Bis-aryl urea derivatives as potent and selective LIM kinase (Limk) inhibitors.
Yin et al.