SR 7826

Catalog # Availability Size / Price Qty
5626/10
5626/50
Cat.No. 5626 - SR 7826 | C22H21N5O2 | CAS No. 1219728-20-7
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Description: Potent and selective LIMK inhibitor; antitumor

Chemical Name: N-(2-Hydroxyethyl)-N'-[4,5-methyl-7H-pyrrolo[2,3-d]pyrimidine-4-yl)phenyl]-N-phenylurea

Purity: ≥98%

Product Details
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Biological Activity

Potent and selective LIMK inhibitor (IC50 values are 43, 5536 and 6565 nM for LIMK1, ROCKI and ROCKII, respectively). Inhibits cofilin phosphorylation in A7r5 cells and suppresses migration and invasion of PC-3 cells in vitro. Orally bioavailable.

Technical Data

M.Wt:
387.43
Formula:
C22H21N5O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1219728-20-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Bis-aryl urea derivatives as potent and selective LIM kinase (Limk) inhibitors.
    Yin et al.
    J.Med.Chem., 2015;58:1846

Product Datasheets

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