Catalog Number: 5855
Chemical Name: Ethyl 3-[[[(4-chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-1-pyrrolidinecarboxylate
Biological Activity
Rev-Erbα/β agonist (EC50 = 710 nM; Kd = 800 nM). Alters circadian locomotor activity and core clock hypothalamic gene expression in mice. Induces weight loss in diet-induced obese mice. Brain penetrant.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists.
    Solt et al.
    Nature, 2012;485:62
  2. Small molecule tertiary amines as agonists of the nuclear hormone receptor Rev-erbα.
    Shin et al.
    Bioorg.Med.Chem.Lett., 2012;22:4413
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