= 710 nM; Kd
= 800 nM). Alters circadian locomotor activity and core clock hypothalamic gene expression in mice. Induces weight loss in diet-induced obese mice. Brain penetrant.
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All Tocris products are intended for laboratory research use only.
Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists.
Solt et al.
Small molecule tertiary amines as agonists of the nuclear hormone receptor Rev-erbα.
Shin et al.