Chemical Name: Ethyl 3-[[[(4-chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-1-pyrrolidinecarboxylate
Biological ActivityRev-Erbα/β agonist (EC50 = 710 nM; Kd = 800 nM). Alters circadian locomotor activity and core clock hypothalamic gene expression in mice. Induces weight loss in diet-induced obese mice. Brain penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists.
Solt et al.
Small molecule tertiary amines as agonists of the nuclear hormone receptor Rev-erbα.
Shin et al.
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