Chemical Name: Ethyl 5-[[[[3'-(Methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl][(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]-2-furancarboxylate
Biological ActivitySR 9238 is a potent and selective LXR inverse agonist (IC50 values are 43 and 214 nM for LXRβ and LXRα, respectively). Selectively inhibits liver LXR over peripheral LXR. Exhibits selectivity for LXR over a panel of 20 other nuclear receptors, including FXR. Reduces hepatic steatosis in obese mice.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
A liver-selective LXR inverse agonist that suppresses hepatic steatosis.
Griffett et al.
ACS Chem.Biol., 2013;8:559
Citation for SR 9238
The citations listed below are publications that use Tocris products. Selected citations for SR 9238 include:
1 Citation: Showing 1 - 1
PNPLA3 I148M Variant Impairs Liver X Receptor Signaling and Cholesterol Homeostasis in Human Hepatic Stellate Cells.
Authors: Bruschi Et al.
Hepatol Commun 2019;3:1191
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