SR 9238

Tocris Bioscience | Catalog # 5854

Potent and selective LXR inverse agonist
Tocris Bioscience
Discontinued Product
5854 has been discontinued. View all LXR-like Receptor Inverse Agonists products.

Key Product Details

Description

Potent and selective LXR inverse agonist
View all LXR-like Receptor Inverse Agonists »

Product Description

SR 9238 is a potent and selective LXR inverse agonist (IC50 values are 43 and 214 nM for LXRβ and LXRα, respectively). Selectively inhibits liver LXR over peripheral LXR. Exhibits selectivity for LXR over a panel of 20 other nuclear receptors, including FXR. Reduces hepatic steatosis in obese mice.

Product Specifications for SR 9238

Molecular Weight

595.73

Formula

C31H33NO7S2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

Ethyl 5-[[[[3'-(Methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl][(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]-2-furancarboxylate

CAS Number

1416153-62-2

PubChem ID

71478195

InChI Key

HDZWHJYZJWLTAG-UHFFFAOYSA-N

SMILES

CCOC(C1=CC=C(O1)CN(S(=O)(C2=C(C=C(C=C2C)C)C)=O)CC3=CC=C(C4=CC(S(C)(=O)=O)=CC=C4)C=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 59.57 100

Preparing Stock Solutions for SR 9238

The following data is based on the product molecular weight 595.73.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.68 mL 8.39 mL 16.79 mL
5 mM 0.34 mL 1.68 mL 3.36 mL
10 mM 0.17 mL 0.84 mL 1.68 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

Product Documents for SR 9238

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SR 9238

For research use only

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