Selective LXR inverse agonist. Exhibits no significant activity at other nuclear receptors at maximally effective concentration. Inhibits the Warburg effect and lipogenesis by down-regulation of LXR-mediated gene expression. Selectively reduces cell viability and induces apoptosis in cancer cell lines in vitro
. Suppresses hepatic steatosis and inhibits growth of tumor xenografts in mice.
Soluble to 20 mM in DMSO
Store at +4°C
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All Tocris products are intended for laboratory research use only.
Broad anti-tumor activity of a small molecule that selectively targets the Warburg effect and lipogenesis.
Flaveny et al.
Cancer Cell., 2015;28:42