SSR 149415

Key Product Details

Product Description

SSR 149415 is a potent and selective vasopressin V_1B antagonist (K_i values are 3.7 and 1.3 nM for native and recombinant rat V_1b receptors, respectively). Displays >70-fold selectively for rat V_1B over V_1A, V₂ oxytoxin and a range of other receptors and ion channels. Inhibits AVP-induced glucagon release in In-R1-G9 α-pancreatic cells in vitro. Inhibits stress-induced ACTH release and exhibits anxiolytic-like effects in anxiety models. Orally bioavailable.

Product Specifications for SSR 149415

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SSR 149415

The following data is based on the product molecular weight 630.11.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.59 mL	7.94 mL	15.87 mL
5 mM	0.32 mL	1.59 mL	3.17 mL
10 mM	0.16 mL	0.79 mL	1.59 mL
50 mM	0.03 mL	0.16 mL	0.32 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 14 publications citing the usage of this product.

• Serradeil-Le Gal An overview of SSR149415, a selective nonpeptide vasopressin V_1b receptor antagonist for the treatment of stress-related disorders. CNS Drug Rev. 2005 PMID: 15867952

Product Documents for SSR 149415