SSYA10-001

Tocris Bioscience | Catalog # 7554

Potent coronavirus helicase inhibitor; also inhibits human papillomavirus E6
Tocris Bioscience

Key Product Details

Description

Potent coronavirus helicase inhibitor; also inhibits human papillomavirus E6
View all Antiviral Compounds »

Product Description

SSYA10-001 is a potent coronavirus helicase inhibitor (IC50 values are 0.046 μM and >3 μM for unwinding and ATPase, respectively). Inhibits SARS-CoV-2 Nsp13 helicase (IC50 = 3.5 μM), blocks dsDNA and dsRNA unwinding activities of Nsp13 (IC50 values are 5.3 μM and 5.7 μM respectively). In a SARS-CoV replicon assay SSYA10-001 inhibits (+) sense but not (-) sense RNA synthesis (EC50 = 8.95 μM). Also inhibits human papillomavirus E6 (IC50 = 10 μM)

Product Specifications for SSYA10-001

Molecular Weight

308.37

Formula

C12H12N4O2S2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2,4-Dihydro-5-[[(2-nitrophenyl)thio]methyl]-4-(2-propen-1-yl)-3H-1,2,4-triazole-3-thione

CAS Number

675104-49-1

PubChem ID

2807230

InChI Key

VWFIHGWHMXSTAO-UHFFFAOYSA-N

SMILES

C=CCN1C(NN=C1CSC2=C(N(=O)=O)C=CC=C2)=S

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product.

Product Documents for SSYA10-001

Certificate of Analysis

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Product Specific Notices for SSYA10-001

For research use only

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