ST 045849

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ST 045849 | CAS No. 442665-87-4 | Other Transferase Inhibitors
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Description: O-GlcNAc transferase (OGT) inhibitor

Chemical Name: 2-[(4-Chlorophenyl)imino]tetrahydro-4-oxo-3-(2-tricyclo[,7]dec-1-ylethyl)-2H-1,3-thiazine-6-carboxylic acid

Purity: ≥98%

Product Details

Biological Activity

ST 045849 is an O-GlcNAc transferase (OGT) inhibitor (IC50 = 53 μM). Reduces proliferation and viability of prostate cancer cells in vitro. Depletes intracellular alanine and decreases glucose consumption by cancer cells. Decreases markers of ER stress and apoptosis in pregnant diabetic mice and reduces neural tube defects in embryos from diabetic mice.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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