STAD 2 New
Biological ActivityAKAP disruptor. Selectively binds PKA-RII subunit with high affinity (Kd = 6.2 nM) and blocks its interaction with AKAP. Cell permeable. Selectively permeable to malaria-infected red blood cells and displays antimalarial activity through a PKA-independent mechanism.
(Modifications: Lys-1 = NH2-PEG3-CH2-CO-Lys, X = (S)-2-(4-pentenyl)alanine, X-10 and X-14 stapled together with a double bond)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Investigating PKA-RII specificity using analogs of the PKA:AKAP peptide inhibitor STAD-2.
Bendzunas et al.
The stapled AKAP disruptor peptide STAD-2 displays antimalarial activity through a PKA-independent mechanism.
Flaherty et al.
PLoS One, 2015;10:e0129239
Isoform-selective disruption of AKAP-localized PKA using hydrocarbon stapled peptides.
Wang et al.
ACS Chem.Biol., 2014;9:635
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